IP10-DT immunotoxin (CAT#: AGTO-L073D)

This immunotoxin was achieved by conjugating/fusing the IP10 to Diphtheriatoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to Th1 cells. Once bind, the toxin enters cells by receptor-mediated endocytosis, then Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme; -II binding and elongation factor into the eukaryotic cell; the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs; thereby preventing protein synthesis and causes cell death. It was designed for treatment of Autoimmune diseases.


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Specifications

  • Host Species
  • Human
  • Species Reactivity
  • Human
  • Molecule Class
  • IP10-DT
  • Toxin Description
  • Diphtheria toxin (Diphtheriatoxin, DT) is a cell toxin produced by diphtheria, is a protein toxin most commonly used in the construction of recombinant immunotoxin. Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme, -II binding and elongation factor into the eukaryotic cell, the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs, thereby preventing protein synthesis and causes cell death.
  • Applications
  • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
  • Related Disease
  • Autoimmune diseases

Target

  • Alternative Names
  • C-X-C chemokine receptor type 3; CD 183; CD182; CD183; Chemokine (C X C motif) receptor 3; Chemokine (C X C) receptor 3; Chemokine CXC Motif Receptor 3; CKR L2; CKR-L2; CKRL2; CMKAR3; CXC-R3; CXCR-3; CXCR3; CXCR3_HUMAN; G Protein Coupled Receptor 9; G protein-coupled receptor 9; GPR9; Interferon-inducible protein 10 receptor; IP-10 receptor; IP10; IP10 R; IP10 receptor; IP10-R; IP10R; Mig R; Mig receptor; Mig-R; MIGR; Autoimmune diseases; Diphtheria toxin; Diphtheria-toxin; DT; DT388; DT389; DT390; DAB389

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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Humanized Antibody

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Blocking Antibody

CAT Product Name Application Type
NEUT-678CQ Mouse Anti-CXCR3 Recombinant Antibody (clone G025H7) FC, Block Mouse IgG1, κ
NEUT-683CQ Hamster Anti-Cxcr3 Recombinant Antibody (clone CXCR3-173) FC, Block Hamster IgG

Neutralizing Antibody

CAT Product Name Application Type
NEUT-679CQ Mouse Anti-CXCR3 Recombinant Antibody (clone 2Ar1) ICC, IF, IHC-P, IHC-Fr, Neut, FC Mouse IgG1
NEUT-680CQ Mouse Anti-CXCR3 Recombinant Antibody (clone CBL045) FC, IHC, Neut Mouse IgG1
NEUT-681CQ Mouse Anti-CXCR3 Recombinant Antibody (clone CBL794) FC, IHC, CyTOF®, Neut Mouse IgG1
NEUT-682CQ Mouse Anti-CXCR3 Recombinant Antibody (clone MM0223-7K22) IHC-Fr, Neut, FC Mouse IgG1

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0888 Hi-Affi™ Rabbit Anti-CXCR3 Recombinant Antibody (clone DS888AB) WB, ICC, IF, IP Rabbit IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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