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Infliximab (TP-088CL)

Tumor necrosis factor (TNF-alpha) binding antibody (chimeric IgG1). It is composed of human constant and murine variable regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion      

Specifications
Classify
Protein therapeutics that interfere with a molecule or organism: Immunoregulation
Therapeutic
Infliximab
Trade Name
Remicade
Function
Chimeric mAb that binds and neutralizes TNFa, preventing induction of pro-inflammatory cytokines, changes in endothelial permeability, activation of eosinophils and neutrophils, induction of acute phase reactants, and enzyme elaboration by synoviocytes and/or chondrocytes
Examples of Clinical Use
Rheumatoid arthritis, crohn's disease, ankylosing spondylitis, psoriatic arthritis, plaque psoriasis
References
Synonyms
Ig gamma-1 chain C region
UniProt
P01857
Genbank
J00228

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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