Products

Insulin Human (TP-002CL)

Insulin human is a 51 residue peptide hormone, composed of two amino acid chains covalently linked by disulfide bonds. The structure is identical to native human insulin. Recombinant insulin is synthesized by recombinant DNA techncology. Inserting the human insulin gene into the Escherichia coli bacteria or Saccharomyces cerevisiae produces insulin for human use.

Inhalable insulin is a powdered form of insulin regular, delivered with a nebulizer into the lungs where it is absorbed. Exubera, developed by Inhale Therapeutics (later named Nektar Therapeutics), became the first inhaled insulin product to be marketed in 2006 by Pfizer, but poor sales led Pfizer to withdraw it in 2007. Afrezza, a monomeric inhaled insulin developed by Mannkind, was approved by the FDA in 2014.      

Specifications
Classify
Protein therapeutics replacing a protein that is deficient or abnormal: Endocrine disorders (hormone deficiencies)
Therapeutic
Insulin human inhalation
Trade Name
Exubera
Function
Insulin formulated for inhalation with faster onset of action
Examples of Clinical Use
Diabetes mellitus
References
Synonyms
Inhaled insulin, Insulin (human), Insulin human, Insulin human [rDNA origin], Insulin Human Regular, Insulin Recombinant Human, Insulin Recombinant Purified Human, Insulin regular, Regular Insulin, human
UniProt
Q8HXV2
Genbank
AY137503

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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