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Kunitz domains anti-PLA (SKD-L118)

The Kunitz domain that bound plasmin was isolated from the library using Phage display techonology. Kunitz domains are stable as standalone peptides, able to recognise specific protein structures, and also work as competitive protease inhibitors in their free form. After affinity maturation, Kunitz domains variants were identified having affinities (KD=87 pM) for plasmin as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.      

Specifications
Scaffold Name
Kunitz domains
Origin
LACI-D1
Core Structure
α-helices, β-sheets
Variable Regions
4, 5 or 9 aa
Target
Plasmin
Species Reactivity
Human
Expression Host
E. coli
Affinity Constant
87 pM
Applications
ELISA; IHC; Microscopy; FC; WB; FuncS
Target
Alternative Names
LACI-D1; Kunitz domains; PLA; human plasmin; plasmin

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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