Anti-CEACAM5-CL3-SN-38 ADC (CAT#: ADC-093LCT)

This ADC product is composed of an anti-CEACAM5 antibody conjuagated via a CL3 linker to SN-38 (CL3-SN-38). It has demonstrated a response in colon carcinoma treatment by a MOA (Mechanism of Action) of Inhibit Topoisomerase I and cause DNA damage.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Antibody Overview
  • Humanized IgG1 monoclonal Antibody (Anti-CEACAM5)
  • Antibody Isotype
  • IgG1
  • Linker
  • CL3
  • Linker Class/Description
  • Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
  • Drug
  • SN-38 (7-ethyl-10-hydroxycamptothecin)
  • Drug Class/Description
  • SN38 (7-ethyl-10-hydroxy camptothecin) is an active metabolite of the cancer prodrug, irinotecan, with the ability of inhibiting Topoisomerase I, which is belong to the camptothecin family. SN-38 is formed via hydrolysis of irinotecan by carboxylesterases and metabolized via glucuronidation by UGT1A1.

Target

  • Introduction
  • Members of the CEACAM subfamily, including CEACAM5, belong to the CEA gene family. For general information on the CEA gene family, see CEACAM1 (MIM 109770).[supplied by OMIM, Oct 2009]
  • Alternative Names
  • CEACAM5; carcinoembryonic antigen-related cell adhesion molecule 5; CEA; CD66e; meconium antigen 100;

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Recombinant Antibody

Immunotoxin

CAT Product Name Application Type
AGTO-L003E anti-CEACAM5 immunotoxin BDI-1 (IgG)-PE Cytotoxicity assay, Functional assay
AGTO-L003R anti-CEACAM5 immunotoxin BDI-1 (IgG)-RTA Cytotoxicity assay, Functional assay
AGTO-L004E anti-CEACAM5 immunotoxin BDI-1 (scFv)-PE Cytotoxicity assay, Functional assay
AGTO-L004R anti-CEACAM5 immunotoxin BDI-1 (scFv)-RTA Cytotoxicity assay, Functional assay

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0118MZ Chicken Anti-CEACAM5 Polyclonal IgY WB Chicken antibody

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0649 Hi-Affi™ Rabbit Anti-CEACAM5 Recombinant Antibody (clone DS649AB) IHC Rabbit IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-703 Afuco™ Anti-CEACAM5 ADCC Recombinant Antibody (Altumomab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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