Products

Laronidase (TP-018CL)

Human recombinant alpha-L-iduronidase, 628 residues (mature form), produced by recombinant DNAtechnology in a Chinese hamster ovary cell line. Laronidase is a glycoprotein with a molecular weight of approximately 83 kD. The predicted amino acid sequence of the recombinant form, as well as the nucleotide sequence that encodes it, are identical to a polymorphic form of human a-L-iduronidase. It contains 6 N-linked oligosaccharide modification sites.      

Specifications
Classify
Protein therapeutics replacing a protein that is deficient or abnormal: Metabolic enzyme deficiencies
Therapeutic
Laronidase (α-L-iduronidase)
Trade Name
Aldurazyme
Function
Digests endogenous glycosaminoglycans (GAGs) within lysosomes, and thereby prevents an accumulation of GAGs that can cause cellular, tissue, and organ dysfunction
Examples of Clinical Use
Hurler and Hurler-scheie forms of mucopolysaccharidosis i
References
Synonyms
Alpha-L-iduronidase precursor
UniProt
P35475
Genbank
M74715

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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