Lutropin alfa (CAT#: TP-036CL)
Lutropin alfa is a recombinant human luteinizing hormone produced in yeast with 2 subunits, alpha = 92 residues, beta = 121 residues. It is a heterodimeric glycoprotein. Each monomeric unit is a glycoprotein molecule. In females, an acute rise of LH ("LH surge") triggers ovulation and the development of the corpus luteum. In males, it stimulates Leydig cell production of testosterone. Lutropin alfa was the first and only recombinant human form of luteinizing hormone (LH) developed for use in the stimulation of follicular development.
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/38925/537_C10_3_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/38925/537_C10_3_selected.jpg
Figure 2 IHC staining of human placenta
(Immunohistochemical staining of human placenta shows strong cytoplasmic positivity in trophoblastic cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/38925/ihc_selected.jpg
(Immunohistochemical staining of human placenta shows strong cytoplasmic positivity in trophoblastic cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/38925/ihc_selected.jpg
Figure 3 IHC staining of human pituitary gland
(High expression. RNA expression: 4493.5 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/ih_additional_tissue/22241/877_299_400x400.jpg
(High expression. RNA expression: 4493.5 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/ih_additional_tissue/22241/877_299_400x400.jpg
Figure 4 IHC staining of human rectum
(Low expression. RNA expression: nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/22241/162609_A_5_3_val_selected.jpg
(Low expression. RNA expression: nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/22241/162609_A_5_3_val_selected.jpg
Figure 5 Liver
(Hepatocytes
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/38925/101358_A_7_4.jpg
(Hepatocytes
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/38925/101358_A_7_4.jpg
Figure 6 Kidney
(Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/38925/101358_A_9_5.jpg
(Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/38925/101358_A_9_5.jpg
Figure 7 Testis
(Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Spermatogonia cells
Staining: Medium
Intensity: Moderate
Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/38925/101358_A_5_6.jpg
(Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Spermatogonia cells
Staining: Medium
Intensity: Moderate
Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/38925/101358_A_5_6.jpg
Figure 8 RNA cell line category: Cell line enhanced (A549, HEK93, Hep G2, K-562, U-266/84)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000104826-LHB
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000104826-LHB
Specifications
- Classify
- Protein therapeutics augmenting an existing pathway: Fertility
- Therapeutic
- Lutropin-α
- Trade Name
- Luveris
- Function
- Recombinant human luteinizing hormone; increases estradiol secretion, thereby supporting follicle-stimulating hormone-induced follicular development
- Examples of clinical use
- Infertility with luteinizing hormone deficiency
References
- Synonyms
- ICSH, Insterstiial cell-stimulating hormone, LH, LH-B, LSH- beta, LSH-B, Luteinizing hormone, Luteinizing hormone beta subunit, Lutrophin, Lutropin alpha, Lutropin beta chain precursor
- UniProt
- P01229
- Genbank
- X00264
Downloads
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0318MZ | Recombinant Mouse Anti-Human LHB Antibody (clone D94) | IHC | Mouse antibody |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2050 | Hi-Affi™ Recombinant Rabbit Anti-LHB Monoclonal Antibody (DS2050AB) | IHC-P | IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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