Anti-CD103 (clone M290)-MCC-DM1 ADC (CAT#: ADC-091LZY)
This ADC product is composed of an anti-CD103 antibody (clone M290) conjugated via MCC linker to DM1 (M290-MCC-DM1). It has demonstrated a response in islet allograft rejection treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 IHC staining of human small intestine
(Immunohistochemical staining of human small intestine shows distinct cytoplasmic positivity in intra-epithelial lymphocytes.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36313/ihc_selected.jpg
(Immunohistochemical staining of human small intestine shows distinct cytoplasmic positivity in intra-epithelial lymphocytes.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36313/ihc_selected.jpg
Figure 2 High expression in small intestine
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/52147/168912_A_4_2_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/52147/168912_A_4_2_selected.jpg
Figure 3 Low expression in cerebral cortex
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/52147/168912_B_9_5_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/52147/168912_B_9_5_val_selected.jpg
Figure 4 Colon
(Enterocytes - Mucosal lymphoid cells Staining: Low Intensity: Moderate Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/52147/168912_A_8_3.jpg
(Enterocytes - Mucosal lymphoid cells Staining: Low Intensity: Moderate Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/52147/168912_A_8_3.jpg
Figure 5 Kidney
(Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/52147/168912_A_8_5.jpg
(Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/52147/168912_A_8_5.jpg
Figure 6 RNA cell line category: Cell line enriched (MOLT-4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000083457-ITGAE
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000083457-ITGAE
Specifications
- Antibody Overview
- Anti-Mouse CD103 mAb,M290
- Clone
- M290
- Linker
- MCC (4-(Nmaleimidomethyl)cyclohexane-1 carboxylate)
- Linker Class/Description
- Class: Noncleavable linker
Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation
- Drug
- DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
- Drug Class/Description
- Class: Maytansinoid
Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells
Target
- Introduction
- Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008]
- Alternative Names
- ITGAE; integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide); CD103; HUMINAE; integrin alpha-E; HML-1 antigen; integrin alpha-IEL; mucosal lymphocyte 1 antigen; antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide;
- Gene ID
- 3682
- UniProt ID
- P38570
Downloads
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Immunotoxin
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G046S | Anti-Itgae immunotoxin M290 (IgG)-Sap | Cytotoxicity assay, Function study |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-741LC | Anti-human ITGAE Recombinant Antibody (5E4) (TAB-741LC) | ELISA, FC | |
| TAB-742LC | Anti-human ITGAE Recombinant Antibody (3G6) (TAB-742LC) | ELISA, FC | |
| TAB-743LC | Anti-human ITGAE Recombinant Antibody (8D5) (TAB-743LC) | ELISA, FC | |
| TAB-741LC-F(E) | Anti-human ITGAE Fab Fragment (5E4) | ELISA, FC | |
| TAB-742LC-F(E) | Anti-human ITGAE Fab Fragment (3G6) | ELISA, FC |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-744LC | Anti-human ITGAE Recombinant Antibody (5E4 (IgG1)) (TAB-744LC) | ELISA, FC | Chimeric antibody (mouse/human) |
| TAB-744LC-S(P) | Anti-human ITGAE scFv Fragment (5E4 (IgG1)) | ELISA, FC | Chimeric antibody (mouse/human) |
| TAB-745LC-S(P) | Anti-human ITGAE scFv Fragment (3G6 (IgG1)) | ELISA, FC | Chimeric antibody (mouse/human) |
| TAB-744LC-F(E) | Anti-human ITGAE Fab Fragment (5E4 (IgG1)) | ELISA, FC | Chimeric antibody (mouse/human) |
| TAB-745LC-F(E) | Anti-human ITGAE Fab Fragment (3G6 (IgG1)) | ELISA, FC | Chimeric antibody (mouse/human) |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0296MZ | Chicken Anti-ITGAE Polyclonal IgY | WB | Chicken antibody |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1558CQ | Recombinant Rat Anti-Itgae Antibody (MAB0828) | BL, FC, IHC-Fr, IP | IgG2 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1877 | Hi-Affi™ Recombinant Rabbit Anti-ITGAE Monoclonal Antibody (DS1877AB) | WB | IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-0851-CN | Recombinant Rabbit Anti-ITGAE Monoclonal Antibody (CBACN-312) | IHC | Rabbit IgG |
| FN-104CQ | Recombinant Rat Anti-ITGAE Antibody (M290) | IF, Neut, FC | Rat IgG2a |
| FN-165CQ | Recombinant Armenian hamster Anti-ITGAE Antibody (2E7) | FC, FuncS, IHC-Fr | Armenian hamster IgG |
| FN-166CQ | Recombinant Rat Anti-ITGAE Antibody (30-F11) | FC, FuncS, IHC, IP | Rat IgG2b, κ |
| ZG-0750F | Mouse Anti-ITGAE Recombinant Antibody (clone AX.14) | FC | Mouse IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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