Anti-FRα (clone M9346A)-SPDB-DM4 ADC (CAT#: ADC-073LZY)
This ADC product is composed of an anti-FRα antibody (clone M9346A) conjugated via SPDB linker to DM4 (M9346A-SPDB-DM4). It is in Phase II clinical trials and has demonstrated a response in FRα+solid tumors, Platinum-resistant epithelial ovarian cancer treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.
Specific Inquiry
Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line HeLa
(Immunofluorescent staining of human cell line HeLa shows localization to nuclear membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/77030/1659_B3_2_selected.jpg
(Immunofluorescent staining of human cell line HeLa shows localization to nuclear membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/77030/1659_B3_2_selected.jpg
Figure 2 RNA cell line category: Group enriched (HeLa, RPTEC TERT1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110195-FOLR1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110195-FOLR1
Figure 2 RNA cell line category: Group enriched (HeLa, RPTEC TERT1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110195-FOLR1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110195-FOLR1
Specifications
- Antibody Overview
- Humanized Anti-FRα,M9346A
- Clone
- M9346A
- Linker
- SPDB (N-succinimidyl 4-(2-pyridyldithio)butyrate)
- Linker Class/Description
- Class: Chemically cleavable Linker-Disulfide Linker
Description: Disulfide Linkers are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.
- Drug
- DM4(N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
- Drug Class/Description
- Class: Maytansinoid
Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells
Target
- Introduction
- The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]
- Alternative Names
- FOLR1; folate receptor 1 (adult); FBP; FOLR; folate receptor alpha; FR-alpha; KB cells FBP; folate binding protein; folate receptor, adult; adult folate-binding protein; ovarian tumor-associated antigen MOv18;
- Gene ID
- 2348
- UniProt ID
- A0A024R5H1
Downloads
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Intrabody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B029(A) | Recombinant Anti-human FOLR1 Intrabody [(D-Arg)9] | PCA, Neut, FuncS | scFv-(D-Arg)9 |
| IAB-B029(G) | Recombinant Anti-human FOLR1 Intrabody [+36 GFP] | WB, Neut, FuncS | scFv-(+36GFP) |
| IAB-B029(T) | Recombinant Anti-human FOLR1 Intrabody [Tat] | WB, ICC, Neut, FuncS | scFv-Tat |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-113 | Anti-Human folate receptor 1 Recombinant Antibody (Farletuzumab) | FC, IP, ELISA, Neut, FuncS, IF, ICC | IgG1 - kappa |
| TAB-019CQ | Human Anti-FOLR1 Recombinant Antibody (TAB-019CQ) | ELISA, WB, IHC | Human IgG1, κ |
| TAB-019CQ-S(P) | Human Anti-FOLR1 Recombinant Antibody; scFv Fragment (TAB-019CQ-S(P)) | ELISA, WB, IHC | Human scFv |
| TAB-019CQ-F(E) | Human Anti-FOLR1 Recombinant Antibody; Fab Fragment (TAB-019CQ-F(E)) | ELISA, WB, IHC | Humanized Fab |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-016CQ | Human Anti-FOLR1 Recombinant Antibody (TAB-016CQ) | ELISA, FC, WB | Human IgG |
| TAB-016CQ-S(P) | Human Anti-FOLR1 Recombinant Antibody; scFv Fragment (TAB-016CQ-S(P)) | ELISA, FC, WB | Human scFv |
| TAB-016CQ-F(E) | Human Anti-FOLR1 Recombinant Antibody; Fab Fragment (TAB-016CQ-F(E)) | ELISA, FC, WB | Human Fab |
| TAB-382CQ | Anti-Human FOLR1 Recombinant Antibody (KHK2805) | IHC | Human antibody |
| TAB-382CQ-S(P) | Anti-Human FOLR1 Recombinant Antibody scFv Fragment (KHK2805) | IHC | Human antibody |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-017CQ | Rat Anti-FOLR1 Recombinant Antibody (TAB-017CQ) | ELISA, WB, IHC | Rat IgG1, κ |
| TAB-020CQ | Mouse Anti-FOLR1 Recombinant Antibody (TAB-020CQ) | ELISA, FC, WB, IHC | Mouse IgG1 |
| TAB-017CQ-S(P) | Rat Anti-FOLR1 Recombinant Antibody; scFv Fragment (TAB-017CQ-S(P)) | ELISA, WB, IHC | Rat scFv |
| TAB-020CQ-S(P) | Mouse Anti-FOLR1 Recombinant Antibody; scFv Fragment (TAB-020CQ-S(P)) | ELISA, FC, WB, IHC | Mouse scFv |
| TAB-017CQ-F(E) | Rat Anti-FOLR1 Recombinant Antibody; Fab Fragment (TAB-017CQ-F(E)) | ELISA, WB, IHC | Rat Fab |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-018CQ | Human Anti-FOLR1 Recombinant Antibody (TAB-018CQ) | ELISA, WB, IHC | Chimeric (Rat/Human) IgG1, κ |
| TAB-018CQ-S(P) | Human Anti-FOLR1 Recombinant Antibody; scFv Fragment (TAB-018CQ-S(P)) | ELISA, WB, IHC | Human scFv |
| TAB-018CQ-F(E) | Human Anti-FOLR1 Recombinant Antibody; Fab Fragment (TAB-018CQ-F(E)) | ELISA, WB, IHC | Chimeric (Rat/Human) Fab |
Fc Glycosylation
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-029LC | Recombinant Anti-Human FOLR1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Human antibody |
| Gly-030LC | Recombinant Anti-Human FOLR1 Antibody (Fc glycosylation) | ELISA | Human antibody |
| Gly-116LC | Recombinant Anti-Human FOLR1 Antibody (Fc glycosylation) | ELISA | Human antibody |
Low- or Non-fucosylated Oligosaccharide
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-029LC-1 | Recombinant Anti-Human FOLR1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Human antibody |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0624CT | Recombinant Mouse anti-Human FOLR1 Monoclonal antibody (ML37) | FC, ICC/IF, IHC-Fr, IP, WB | |
| HPAB-0080-FY | Human Anti-FOLR1 Recombinant Antibody (HPAB-0080-FY) | FC | Human IgG |
| HPAB-M0094-YC | Human Anti-FOLR1 Recombinant Antibody (HPAB-M0094-YC) | FuncS | Humanized IgG |
| VS3-CJ671 | Rabbit Anti-FOLR1 Recombinant Antibody (VS3-CJ671) | WB, IHC, FC | Rabbit IgG |
| VS-0723-WK144 | Human Anti-FOLR1 Recombinant Antibody (VS-0723-WK144) | FC | Chimeric (rabbit/human) IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1333 | Hi-Affi™ Rabbit Anti-FOLR1 Recombinant Antibody (clone DS1333AB) | WB | Rabbit IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0115-CN-F(E) | Mouse Anti-FOLR1 Recombinant Antibody; Fab Fragment (HPAB-0115-CN-F(E)) | ELISA, FC, IHC | Mouse Fab |
| HPAB-0116-CN-F(E) | Human Anti-FOLR1 Recombinant Antibody; Fab Fragment (HPAB-0116-CN-F(E)) | ELISA, FC, IHC | Humanized Fab |
| HPAB-0117-CN-F(E) | Mouse Anti-FOLR1 Recombinant Antibody; Fab Fragment (HPAB-0117-CN-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-0118-CN-F(E) | Mouse Anti-FOLR1 Recombinant Antibody; Fab Fragment (HPAB-0118-CN-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-0119-CN-F(E) | Mouse Anti-FOLR1 Recombinant Antibody; Fab Fragment (HPAB-0119-CN-F(E)) | ELISA, FC, IHC, WB | Mouse Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-113 | Afuco™ Anti-FOLR1 ADCC Recombinant Antibody (Farletuzumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0312-WJ-S(P) | Mouse Anti-FOLR1 Recombinant Antibody; scFv Fragment (HPAB-0312-WJ-S(P)) | ELISA, IHC, FC | Mouse scFv |
| HPAB-0313-WJ-S(P) | Mouse Anti-FOLR1 Recombinant Antibody; scFv Fragment (HPAB-0313-WJ-S(P)) | ELISA, IHC, FC | Mouse scFv |
| HPAB-0314-WJ-S(P) | Mouse Anti-FOLR1 Recombinant Antibody; scFv Fragment (HPAB-0314-WJ-S(P)) | ELISA, IHC, FC | Mouse scFv |
| HPAB-M0094-YC-S(P) | Human Anti-FOLR1 Recombinant Antibody; scFv Fragment (HPAB-M0094-YC-S(P)) | FuncS | Humanized scFv |
| HPAB-N0093-YC-S(P) | Human Anti-FOLR1 Recombinant Antibody; scFv Fragment (HPAB-N0093-YC-S(P)) | ELISA | Humanized scFv |
MHC Tetramer for Cancer
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0049 | APC-A*02:01/Human FBP (EIWTHSYKV) MHC Tetramer | FCM | |
| MHC-CN0050 | PE-A*02:01/Human FBP (EIWTHSYKV) MHC Tetramer | FCM | |
| MHC-CN0685 | PE-A*02:01/Human FOLR1 (EIWTHSYKV) MHC Tetramer | FCM, IHC | |
| MHC-CN0686 | APC-A*02:01/Human FOLR1 (EIWTHSYKV) MHC Tetramer | FCM, IHC | |
| MHC-CN0687 | FITC-A*02:01/Human FOLR1 (EIWTHSYKV) MHC Tetramer | FCM, IHC |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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