Anti-CD19 (clone MDX1435)-vc-duocarmycin ADC (CAT#: ADC-163LZY)
This ADC product is composed of an anti-CD19 antibody (clone MDX1435) conjugated via vc linker to duocarmycin (MDX1435-vc-duocarmycin). It has demonstrated a response in non-Hodgkin's lymphoma treatment by a MOA (Mechanism of Action) as DNA minor groove binding alkylating agent.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Colon
(Mucosal lymphoid cells
Staining:Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_7_3.jpg
(Mucosal lymphoid cells
Staining:Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_7_3.jpg
Figure 2 Testis
(Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_5_6.jpg
(Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_5_6.jpg
Figure 3 Appendix
(Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_2_2.jpg
(Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_2_2.jpg
Figure 4 Lymph node
(Germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_9_8.jpg
(Germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_9_8.jpg
Figure 5 RNA cell line category: Cell line enhanced (Daudi, REH, U-698)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000177455-CD19
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000177455-CD19
Specifications
- Antibody Overview
- MDX1435 (Fully Human Anti-CD19 mAb)
- Clone
- MDX1435
- Linker
- VC (valine-citrulline)
- Linker Class/Description
- Class: Enzymatically cleavable linker-Peptide linker
Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Drug
- duocarmycin
- Drug Class/Description
- Class: Duocarmycin
Description: Duocarmycins belong to the minor-groove-binding DNA-alkylating agents (DNA MGBA). The natural duocarmycins are isolated from the culture broth of Streptmyces sp and a series of derivatives has also been synthesized
Target
- Introduction
- Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008]
- Alternative Names
- CD19; CD19 molecule; B4; CVID3; B-lymphocyte antigen CD19; differentiation antigen CD19; T-cell surface antigen Leu-12; B-lymphocyte surface antigen B4;
- Gene ID
- 930
- UniProt ID
- P15391
Related Resources
Primary Immunodeficiency
Downloads
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See other products for "CD19"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1087z | Mouse Anti-CD19 Recombinant Antibody (clone 32B9) | WB, FC, ICC, IF, FuncS | Mouse IgG1 |
| HPAB-0023LY | Humanized Anti-CD19 Recombinant Antibody (HPAB-0023LY) | WB, FC, Cyt | Humanized IgG1 |
| HPAB-0036LY | Recombinant Humanized Anti-CD19 Antibody (Hbu12) | WB, IHC | |
| HPAB-0418LY | Human Anti-CD19 Recombinant Antibody (HPAB-0418LY) | Cyt, BLI, FC, FuncS, ELISA, WB, RIA | Human IgG1 |
| HPAB-0419LY | Human Anti-CD19 Recombinant Antibody (HPAB-0419LY) | ELISA, WB, FC, RIA | Human IgG1 |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H17 | Anti-Human CD19 Recombinant Antibody (Denintuzumab Mafodotin) | IF, IP, Neut, FuncS, ELISA, FC, WB | IgG1 - kappa |
| TAB-891 | Humanized Anti-CD19 Recombinant Antibody (clone Denintuzumab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | Humanized IgG1, κ |
| TAB-1612CL | Human Anti-CD19 Recombinant Antibody (TAB-1612CL) | Depletion, FuncS | Humanized IgG1 |
| TAB-1625CL | Anti-Human CD19 Recombinant Antibody (396) | Depletion, ELISA | Humanized antibody |
| TAB-431CQ | Anti-Human CD19 Recombinant Antibody | ELISA, IHC, FC, IP, IF, FuncS | IgG1, κ |
Immunotoxin
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G076E | Anti-CD19 immunotoxin HD37 (IgG)-PE | Cytotoxicity assay, Function study | |
| AGTO-G076D | Anti-CD19 immunotoxin HD37 (IgG)-DT | Cytotoxicity assay, Function study | |
| AGTO-G076R | Anti-CD19 immunotoxin HD37 (IgG)-RTA | Cytotoxicity assay, Function study | |
| AGTO-G076S | Anti-CD19 immunotoxin HD37 (IgG)-Sap | Cytotoxicity assay, Function study | |
| AGTO-G076P | Anti-CD19 immunotoxin HD37 (IgG)-PAP | Cytotoxicity assay, Function study |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1613CL | Human Anti-CD19 Recombinant Antibody (TAB-1613CL) | Cyt, FC, FuncS, Inhib | Chimeric (mouse/human) IgG1 |
| TAB-1614CL | Human Anti-CD19 Recombinant Antibody (TAB-1614CL) | FuncS | Chimeric (mouse/human) IgG |
| TAB-1621CL | Anti-Human CD19 Recombinant Antibody (cHD37) | ADCC, FuncS | Chimeric antibody (mouse/human) |
| TAB-1613CL-S(P) | Mouse Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1613CL-S(P)) | Depletion, FuncS | Mouse scFv |
| TAB-1621CL-S(P) | Anti-Human CD19 Recombinant Antibody scFv Fragment (cHD37) | FuncS | Chimeric antibody (mouse/human) |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1626CL-S(P) | Anti-Human CD19 Recombinant Antibody scFv Fragment (HB12a) | Depletion | Fully human antibody |
| TAB-1627CL-S(P) | Anti-Human CD19 Recombinant Antibody scFv Fragment (HB12b) | Depletion | Fully human antibody |
| TAB-1616CL-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1616CL-F(E)) | ELISA, WB | Human Fab |
| TAB-1626CL-F(E) | Anti-Human CD19 Recombinant Antibody Fab Fragment (HB12a) | Depletion | Fully human antibody |
| TAB-1627CL-F(E) | Anti-Human CD19 Recombinant Antibody Fab Fragment (HB12b) | Depletion | Fully human antibody |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1611CL-F(E) | Mouse Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1611CL-F(E)) | Depletion, FuncS | Mouse Fab |
| TAB-1620CL-F(E) | Anti-Human CD19 Recombinant Antibody Fab Fragment (HD37) | FuncS | |
| TAB-1622CL-F(E) | Mouse Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1622CL-F(E)) | ELISA, FC, Apop, ADCC, FuncS | Mouse Fab |
| TAB-1623CL-F(E) | Mouse Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1623CL-F(E)) | ELISA, FC | Mouse Fab |
| TAB-1624CL-F(E) | Anti-Human CD19 Recombinant Antibody Fab Fragment (381) | FC, Inhib, ELISA |
Fc Glycosylation
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-061LC | Recombinant Anti-Human CD19 Antibody (Fc glycosylation/Low fucosylated) | ELISA, FC | Chimeric antibody (mouse/human) |
| Gly-105LC | Recombinant Anti-Human CD19 Antibody (Fc glycosylation) | ELISA | Mouse antibody |
| Gly-141LC | Recombinant Anti-Human CD19 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
Low- or Non-fucosylated Oligosaccharide
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-061LC-1 | Recombinant Anti-Human CD19 Antibody (Fc glycosylation/Low fucosylated) | ELISA, FC | Chimeric antibody (mouse/human) |
| Gly-141LC-1 | Recombinant Anti-Human CD19 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0100MZ | Chicken Anti-CD19 Polyclonal IgY | WB | Chicken antibody |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-286CQ | Mouse Anti-CD19 Recombinant Antibody (clone SJ25-C1) | Neut, FC, IHC, IHC-Fr, IP | Mouse IgG1 |
| NEUT-287CQ | Mouse Anti-CD19 Recombinant Antibody (clone HIB19) | FC, CyTOF, IHC, Block | Mouse IgG1, κ |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-288CQ | Rat Anti-CD19 Recombinant Antibody (clone 1D3) | Depletion, Block, FC | Rat IgG2a |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0538 | Hi-Affi™ Rabbit Anti-CD19 Recombinant Antibody (clone DS538AB) | IHC-P | Rabbit IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0267-CN-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (HPAB-0267-CN-F(E)) | ELISA, FC | Humanized Fab |
| HPAB-0268-CN-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (HPAB-0268-CN-F(E)) | ELISA, FC | Human Fab |
| HPAB-0269-CN-F(E) | Mouse Anti-CD19 Recombinant Antibody; Fab Fragment (HPAB-0269-CN-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-0270-CN-F(E) | Human Anti-CD19 Recombinant Antibody; Fab Fragment (HPAB-0270-CN-F(E)) | FC | Humanized Fab |
| HPAB-0023LY-F(E) | Humanized Anti-CD19 Recombinant Antibody; Fab Fragment (HPAB-0023LY-F(E)) | WB | Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-616-FY-S(P) | Human Anti-CD19 Recombinant Antibody; scFv Fragment (HPAB-616-FY-S(P)) | ELISA | Human scFv |
| HPAB-0367-FY-S(P) | Human Anti-CD19 Recombinant Antibody; scFv Fragment (HPAB-0367-FY-S(P)) | WB, ELISA, FC | Human scFv |
| HPAB-0368-FY-S(P) | Human Anti-CD19 Recombinant Antibody; scFv Fragment (HPAB-0368-FY-S(P)) | WB, ELISA, FC | Human scFv |
| FAMAB-0071WJ-S(P) | Mouse Anti-CD19 Recombinant Antibody (clone 25C1); scFv Fragment | WB, FC | Human scFv |
| FAMAB-0072WJ-S(P) | Mouse Anti-CD19 Recombinant Antibody (clone BLY3); scFv Fragment | WB, FC | Human scFv |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-174 | Afuco™ Anti-CD19 ADCC Recombinant Antibody (Taplitumomab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
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