Mecasermin (CAT#: TP-009CL)
Mecasermin contains recombinant-DNA-engineered human insulin-like growth factor-1 (rhIGF-1). IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges and a molecular weight of 7649 daltons. The amino acid sequence of the product is identical to that of endogenous human IGF-1. The rhIGF-1 protein is synthesized in bacteria (E. coli) that have been modified by the addition of the gene for human IGF-1.
Specifications
- Classify
- Protein therapeutics replacing a protein that is deficient or abnormal: Endocrine disorders (hormone deficiencies)
- Therapeutic
- Mecasermin
- Trade Name
- Increlex
- Function
- Recombinant insulin-like growth factor 1 (iGF1) induces mitogenesis, chondrocyte growth and organ growth, which combine to restore appropriate statural growth
- Examples of clinical use
- Growth failure in children with GH gene deletion or severe primary iGF1 deficiency
References
- Synonyms
- IGF-1, IGF1, Insulin-like growth factor 1, Mecasermin recombinant, Mecasermin rinfabate, Mecasermin rinfabate recombinant, Mechano growth factor, Somatomedin-C
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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