Products

Mecasermin (TP-009CL)

Mecasermin contains recombinant-DNA-engineered human insulin-like growth factor-1 (rhIGF-1). IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges and a molecular weight of 7649 daltons. The amino acid sequence of the product is identical to that of endogenous human IGF-1. The rhIGF-1 protein is synthesized in bacteria (E. coli) that have been modified by the addition of the gene for human IGF-1.      

Specifications
Classify
Protein therapeutics replacing a protein that is deficient or abnormal: Endocrine disorders (hormone deficiencies)
Therapeutic
Mecasermin
Trade Name
Increlex
Function
Recombinant insulin-like growth factor 1 (iGF1) induces mitogenesis, chondrocyte growth and organ growth, which combine to restore appropriate statural growth
Examples of Clinical Use
Growth failure in children with GH gene deletion or severe primary iGF1 deficiency
References
Synonyms
IGF-1, IGF1, Insulin-like growth factor 1, Mecasermin recombinant, Mecasermin rinfabate, Mecasermin rinfabate recombinant, Mechano growth factor, Somatomedin-C

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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