Anti-cKIT (clone NEG026)-SMCC-DM1 ADC (CAT#: ADC-100CL)

This ADC product is composed of an anti-cKIT antibody (clone NEG026) conjugated via SMCC linker to DM1 (NEG026-MCC-DM1). It has demonstrated a response in cancer treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Antibody Overview
  • Anti-cKIT Antibody NEG026
  • Clone
  • NEG026
  • Linker
  • SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
  • Linker Class/Description
  • Class: Noncleavable linkers
    Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.
  • Drug
  • DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
  • Drug Class/Description
  • Class: Maytansinoid
    Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
    macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.

Target

  • Introduction
  • This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Alternative Names
  • KIT; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; PBT; SCFR; C-Kit; CD117; mast/stem cell growth factor receptor Kit; p145 c-kit; proto-oncogene c-Kit; piebald trait protein; soluble KIT variant 1; tyrosine-protein kinase Kit; proto-oncogene tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein;

Downloads

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Humanized Antibody

CAT Product Name Application Type
TAB-470CL Human Anti-KIT Recombinant Antibody (TAB-470CL) ELISA, WB Human IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-450CL Afuco™ Anti-KIT Recombinant Antibody (AFC-450CL), ADCC Enhanced ELISA, WB Humanized IgG1

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0316MZ Chicken Anti-KIT Polyclonal IgY WB Chicken antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-1629CQ Recombinant Mouse Anti-KIT Antibody (A3C6E2) FC, BL IgG1, κ
NEUT-1633CQ Recombinant Rat Anti-Kit Antibody (ACK2) FC, BL, Depletion IgG2b, κ

Neutralizing Antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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