Products

Oprelvekin (TP-033CL)

Oprelvekin, the active ingredient in Neumega® is recombinant Interleukin eleven, which is produced in Escherichia coli (E. coli) by recombinant DNA technology. The protein has a molecular mass of approximately 19,000 daltons, and is non-glycosylated. The polypeptide is 177 amino acids in length (the natural IL-11 has 178). This alteration has not resulted in measurable differences in bioactivity either in vitro or in vivo.

The primary hematopoietic activity of Neumega® is stimulation of megakaryocytopoiesis and thrombopoiesis. In mice and nonhuman primate studies Neumega® has shown potent thrombopoietic activity in compromised hematopoiesis, including moderately to severely myelosuppressed animals. In these studies, Neumega® improved platelet nadirs and accelerated platelet recoveries compared to controls.

In animal studies Oprelvekin also has non-hematopoetic activities. This includes the regulation of intestinal epithelium growth (enhanced healing of gastrointestinal lesions), the inhibition of adipogenesis, the induction of acute phase protein synthesis (e.g., fibrinogen), and inhibition of macrophageal released pro-inflammatory cytokines.      

Specifications
Classify
Protein therapeutics augmenting an existing pathway: Haematopoiesis
Therapeutic
Oprelvekin (interleukin11; iL11)
Trade Name
Neumega
Function
Stimulates megakaryocytopoiesis and thrombopoiesis
Examples of Clinical Use
Prevention of severe thrombocytopaenia, especially after myelosuppressive chemotherapy
References
Synonyms
Adipogenesis inhibitory factor, AGIF, IL-11, Interleukin-11 precursor
UniProt
P20809
Genbank
M57765

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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