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PDZ domain anti-GRIK2 (SPD-L162)

The PDZ domain that bound GluR6 was isolated from the library using Phage display techonology. PDZ domains are modular protein-interaction domains that are specialized for binding to short peptide motifs at the extreme carboxy (C) termini of other proteins, athough they can also have other modes of interaction. After affinity maturation, PDZ domain variants were identified having affinities (KD=20 nM) for GluR6 as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.      

Specifications
Scaffold Name
PDZ domain
Origin
PSD-95 protein
Core Structure
β-sheet
Target
GluR6
Species Reactivity
Human
Expression Host
E. coli
Affinity Constant
20 nM
Applications
ELISA; IHC; Microscopy; FC; WB; FuncS
Target
Alternative Names
PSD-95 protein; PDZ domain; EAA4; GLR6; MRT6; GLUK6; GLUR6; GluK2
Entrez Gene ID
2898
UniProt ID
Q13002

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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