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PDZ domain anti-HTR2A (SPD-L154)

The PDZ domain that bound 5-HT2C Receptor was isolated from the library using Phage display techonology. PDZ domains are modular protein-interaction domains that are specialized for binding to short peptide motifs at the extreme carboxy (C) termini of other proteins, athough they can also have other modes of interaction. After affinity maturation, PDZ domain variants were identified having affinities for 5-HT2C Receptor as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.      

Specifications
Scaffold Name
PDZ domain
Origin
PSD-95 protein
Core Structure
β-sheet
Target
5-HT2C Receptor
Species Reactivity
Human
Expression Host
E. coli
Applications
ELISA; IHC; Microscopy; FC; WB; FuncS
Target
Alternative Names
PSD-95 protein; PDZ domain; HTR2; 5-HT2A
Entrez Gene ID
3358
UniProt ID
P28223

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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