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PE-A*02:01/Human CD59 (SLSEKTVLL) MHC Tetramer (CAT#: MHC-LC1980)

This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human CD59 of peptide SLSEKTVLL covering 106-114 and A*02:01 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.


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Specific Inquiry
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  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Figure 1 IF staining of human cell line A-431
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to the Golgi apparatus & vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26494/279_B8_2_selected.jpg
Figure 2 IHC staining of human urinary bladder
Figure 2 IHC staining of human urinary bladder
(Immunohistochemical staining of human urinary bladder shows distinct membranous positivity in urothelial cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26494/ihc_selected.jpg
Figure 3 IF staining of human cell line PC-3
Figure 3 IF staining of human cell line PC-3
(Immunofluorescent staining of human cell line PC-3 shows localization to the vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26494/1432_F1_2_blue_red_green.jpg
Figure 4 IF staining of human cell line U-2 OS
Figure 4 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26494/280_B8_1_blue_red_green.jpg
Normal Tissue
Figure 5 Cerebral cortex
Figure 5 Cerebral cortex
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26494/55053_B_8_5.jpg
Figure 6 Colon
Figure 6 Colon
(Endothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26494/55159_A_7_3.jpg
Figure 7 Urinary bladder
Figure 7 Urinary bladder
(Urothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26494/55159_A_6_5.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (TIME, U-2197)
Figure 8 RNA cell line category: Cell line enhanced (TIME, U-2197)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000085063-CD59
Figure 8 RNA cell line category: Cell line enhanced (TIME, U-2197)
Figure 8 RNA cell line category: Cell line enhanced (TIME, U-2197)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000085063-CD59

Specifications

  • Allele
  • A*02:01
  • Class
  • Class I
  • Antigen
  • CD59
  • Antigen Species
  • Human
  • Peptide
  • SLSEKTVLL
  • Range
  • 106-114
  • Conjugate
  • PE
  • Application
  • FCM

Target

  • Antigen Introduction
  • This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
  • Alternative Names
  • CD59; CD59 glycoprotein precursor; 1F5; EJ16; EJ30; EL32; G344; MIN1; MIN2; MIN3; MIRL; HRF20; MACIF; MEM43; MIC11; MSK21; 16.3A5; HRF-20; MAC-IP; p18-20

Downloads

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See other products for "CD59"

Recombinant Antibody

CAT Product Name Application Type
MOB-1088z Mouse Anti-CD59 Recombinant Antibody (clone 18C6) FC, IF, FuncS Mouse IgM, κ
MOB-0520CT Recombinant Mouse anti-Human CD59 Monoclonal antibody (2G6) FC
MRO-0311-CN Rabbit Anti-CD59 Recombinant Antibody (clone JM10-71) WB, IF, FC, IP Rabbit IgG
FAMAB-1074CQ Mouse Anti-CD59 Recombinant Antibody (clone YTH 53.1) FC Mouse IgG1
VS2-QX20 Mouse Anti-CD59 Recombinant Antibody (clone BRIC 229) WB, FuncS Mouse IgG2b, κ

Human Antibody

CAT Product Name Application Type
TAB-319LC Human Anti-CD59 Recombinant Antibody (TAB-319LC) ELISA, FC, Inhib Human IgG1
TAB-319LC-S(P) Human Anti-CD59 Recombinant Antibody; scFv Fragment (TAB-319LC-S(P)) ELISA Human scFv
TAB-319LC-F(E) Human Anti-CD59 Recombinant Antibody; Fab Fragment (TAB-319LC-F(E)) ELISA Human Fab

Chimeric Antibody

CAT Product Name Application Type
TAB-321LC Anti-Human CD59 Recombinant Antibody ((ch)AR36A36.11.1) ELISA, FuncS, WB Chimeric antibody (mouse/human)
TAB-321LC-S(P) Anti-Human CD59 Recombinant Antibody scFv Fragment ((ch)AR36A36.11.1) WB, ELISA Chimeric antibody (mouse/human)
TAB-321LC-F(E) Anti-Human CD59 Recombinant Antibody Fab Fragment ((ch)AR36A36.11.1) WB, ELISA Chimeric antibody (mouse/human)

Mouse Antibody

CAT Product Name Application Type
TAB-317LC-S(P) Mouse Anti-CD59 Recombinant Antibody; scFv Fragment (TAB-317LC-S(P)) WB, ELISA Mouse scFv
TAB-318LC-S(P) Anti-Human CD59 Recombinant Antibody scFv Fragment (1E8) FC, ELISA
TAB-320LC-S(P) Anti-Human CD59 Recombinant Antibody scFv Fragment (AR36A36.11.1) WB, ELISA
TAB-317LC-F(E) Mouse Anti-CD59 Recombinant Antibody; Fab Fragment (TAB-317LC-F(E)) WB, ELISA Mouse Fab
TAB-318LC-F(E) Anti-Human CD59 Recombinant Antibody Fab Fragment (1E8) FC, ELISA

Humanized Antibody

CAT Product Name Application Type
TAB-322LC-S(P) Anti-Human CD59 Recombinant Antibody scFv Fragment (HV3/KV3 ) WB, ELISA Humanized antibody
TAB-323LC-S(P) Anti-Human CD59 Recombinant Antibody scFv Fragment (HV2/KV3) WB, ELISA Humanized antibody
TAB-324LC-S(P) Anti-Human CD59 Recombinant Antibody scFv Fragment (HV2/KV4) WB, ELISA Humanized antibody
TAB-322LC-F(E) Anti-Human CD59 Recombinant Antibody Fab Fragment (HV3/KV3 ) WB, ELISA Humanized antibody
TAB-323LC-F(E) Anti-Human CD59 Recombinant Antibody Fab Fragment (HV2/KV3) WB, ELISA Humanized antibody

Neutralizing Antibody

CAT Product Name Application Type
NEUT-397CQ Mouse Anti-CD59 Recombinant Antibody (clone MEM-43) Neut, FC, IHC, IHC-P, IP, CyTOF® Mouse IgG2a

Blocking Antibody

CAT Product Name Application Type
NEUT-398CQ Rat Anti-CD59 Recombinant Antibody (clone YTH53.1) Block, FC, ICC, IF, IHC-Fr, IHC-P, WB, FuncS Rat IgG2b

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0572 Hi-Affi™ Rabbit Anti-CD59 Recombinant Antibody (clone DS572AB) WB, IHC Rabbit IgG

MHC Tetramer for Cancer

CAT Product Name Application Type
MHC-LC1953 PE-A2/Human CD59 (SLSEKTVLL) MHC Tetramer FCM

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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