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PE-A*02:01/Human HLA-E (MVDGTLLLL) MHC Tetramer (CAT#: MHC-LC1930)

This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human HLA-E of peptide MVDGTLLLL covering 1-9 and A*02:01 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.


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  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Figure 1 IF staining of human cell line A-431
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/31454/if_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Figure 2 Cerebral cortex
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/24589/57001_B_7_5.jpg
Figure 3 Lung
Figure 3 Lung
(Alveolar cells type II
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Endothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Macrophages
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/24589/57001_A_2_4.jpg
Figure 4 Colon
Figure 4 Colon
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/24589/57001_A_9_3.jpg
Figure 5 Kidney
Figure 5 Kidney
(Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/24589/57001_A_7_5.jpg
Figure 6 Testis
Figure 6 Testis
(Leydig cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/24589/57001_A_6_6.jpg
Figure 7 Lymph node
Figure 7 Lymph node
(Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/24589/57001_A_8_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (ASC diff, U-266/70)
Figure 8 RNA cell line category: Cell line enhanced (ASC diff, U-266/70)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000204592-HLA-E

Specifications

  • Allele
  • A*02:01
  • Class
  • Class I
  • Antigen
  • HLA-E
  • Antigen Species
  • Human
  • Peptide
  • MVDGTLLLL
  • Range
  • 1-9
  • Conjugate
  • PE
  • Application
  • FCM

Target

  • Antigen Introduction
  • HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq, Jul 2008]
  • Alternative Names
  • HLA-E; HLA class I histocompatibility antigen, alpha chain E precursor; QA1; HLA-6.2

Downloads

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See other products for "HLA-E"

Recombinant Antibody

CAT Product Name Application Type
MOB-504 Recombinant Anti-human HLA-E Antibody ELISA, IF, FuncS IgG
MHH-504 Recombinant Human Anti-human HLA-E Antibody ELISA, IF, FuncS IgG
MOB-0943CT Recombinant Mouse anti-Human HLA-E Monoclonal antibody (NFN-F/03) IHC-P, WB
FN-168CQ Mouse Anti-HLA-E Recombinant Antibody (clone 3D12HLA-E) FC, FuncS, Neut, ELISA Mouse IgG1, κ
VS3-QX535 Mouse Anti-HLA-E Recombinant Antibody (clone 4G23) WB, IP, FC Mouse IgG1

Fab Fragment Antibody

CAT Product Name Application Type
MOB-504-F(E) Recombinant Anti-human HLA-E Antibody Fab Fragment RIA, IP, FuncS Fab
MHH-504-F(E) Recombinant Human Anti-human HLA-E Antibody Fab Fragment WB, FC, FuncS Fab

scFv Fragment Antibody

CAT Product Name Application Type
MOB-504-S(P) Recombinant Anti-human HLA-E Antibody scFv Fragment ELISA, WB, FuncS scFv
MHH-504-S(P) Recombinant Human Anti-human HLA-E Antibody scFv Fragment FC, RIA, Biosensors, FuncS scFv

Neutralizing Antibody

CAT Product Name Application Type
NEUT-910CQ Mouse Anti-HLA-E Recombinant Antibody (clone F21-2) WB, Neut, FC, IHC, IHC-Fr, IP Mouse IgG1, κ

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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