PE-A*02:01/Human MC1R (SLCFLGAIA) MHC Tetramer (CAT#: MHC-LC2689)

This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human MC1R of peptide SLCFLGAIA covering 131-139 and A*02:01 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.


Specific Inquiry
  • Size:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
RNA Expression

Specifications

  • Allele
  • A*02:01
  • Class
  • Class I
  • Antigen
  • MC1R
  • Antigen Species
  • Human
  • Peptide
  • SLCFLGAIA
  • Range
  • 131-139
  • Conjugate
  • PE
  • Application
  • FCM

Target

  • Antigen Introduction
  • This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq, Jul 2008]
  • Alternative Names
  • MC1R; Melanocyte-stimulating hormone receptor; CMM5; MSH-R; SHEP2

Downloads

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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