PE-DQB1*03:01/Human PTPRN (GVAGLLVALAV) MHC Tetramer (CAT#: MHC-LC3239)

This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human PTPRN of peptide GVAGLLVALAV covering 586-596 and DQB1*03:01 molecule. The pMHC tetramer recognizes CD4 T cells, and can be used in the analysis of individual antigen-specific T cells.


Specific Inquiry
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Specifications

  • Allele
  • DQB1*03:01
  • Class
  • Class II
  • Antigen
  • PTPRN
  • Antigen Species
  • Human
  • Peptide
  • GVAGLLVALAV
  • Range
  • 586-596
  • Conjugate
  • PE
  • Application
  • FCM

Target

  • Antigen Introduction
  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]
  • Alternative Names
  • PTPRN; Receptor-type tyrosine-protein phosphatase-like N precursor; IA2; IA-2; ICA512; R-PTP-N; IA-2/PTP

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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