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PE-DQB1*03:02/Human HLA-DQB1 (AAEYWNSQKEVLER) MHC Tetramer (CAT#: MHC-LC4550)

This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human HLA-DQB1 of peptide AAEYWNSQKEVLER covering 89-102 and DQB1*03:02 molecule. The pMHC tetramer recognizes CD4 T cells, and can be used in the analysis of individual antigen-specific T cells.


See more MHC Tetramer products for HLA-DQB1
Specific Inquiry
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  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line HEK 293 shows localization to rods & rings.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13667/1729_E2_3_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Figure 2 Cerebral cortex
(Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13667/31953_B_7_5.jpg
Figure 3 Colon
Figure 3 Colon
(Mucosal lymphoid cells
Staining: High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13667/31340_A_7_3.jpg
Figure 4 Kidney
Figure 4 Kidney
(Cells in glomeruli
Staining: High
Intensity: Strong
Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13667/31340_A_9_5.jpg
Figure 5 Lymph node
Figure 5 Lymph node
(Germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13667/31340_A_9_8.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enriched (HDLM-2)
Figure 6 RNA cell line category: Cell line enriched (HDLM-2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000179344-HLA-DQB1

Specifications

  • Allele
  • DQB1*03:02
  • Class
  • Class II
  • Antigen
  • HLA-DQB1
  • Antigen Species
  • Human
  • Peptide
  • AAEYWNSQKEVLER
  • Range
  • 89-102
  • Conjugate
  • PE
  • Application
  • FCM

Target

  • Antigen Introduction
  • HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
  • Alternative Names
  • HLA-DQB1; HLA class II histocompatibility antigen, DQ(3) beta chain; IDDM1; CELIAC1; HLA-DQB

Downloads

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See other products for "HLA-DQB1"

Recombinant Antibody

CAT Product Name Application Type
MOB-502 Recombinant Anti-human HLA-DQB1 Antibody WB, Neut, FuncS IgG
MHH-502 Recombinant Human Anti-human HLA-DQB1 Antibody FC, RIA, Biosensors, FuncS IgG
MOB-0842CT Recombinant Mouse anti-Human HLA-DQB1 Monoclonal antibody (Hfopy 4.64) ELISA, FC, IHC-Fr

Fab Fragment Antibody

CAT Product Name Application Type
MOB-502-F(E) Recombinant Anti-human HLA-DQB1 Antibody Fab Fragment RIA, ELISA, FuncS Fab
MHH-502-F(E) Recombinant Human Anti-human HLA-DQB1 Antibody Fab Fragment ELISA, WB, Dot, FuncS Fab

scFv Fragment Antibody

CAT Product Name Application Type
MOB-502-S(P) Recombinant Anti-human HLA-DQB1 Antibody scFv Fragment FC, RIA, Biosensors, FuncS scFv
MHH-502-S(P) Recombinant Human Anti-human HLA-DQB1 Antibody scFv Fragment ELISA, WB, IP, FuncS scFv

MHC Tetramer for Cancer

CAT Product Name Application Type
MHC-LC3356 PE-DRB1*13:01/Human HLA-DQB1 (TERVRLVTRHIYNREE) MHC Tetramer FCM
MHC-LC3357 PE-DRB1*13:01/Human HLA-DQB1 (TERVRLVTRHIYNRE) MHC Tetramer FCM
MHC-LC3358 PE-DRB1*13:01/Human HLA-DQB1 (TERVRLVTRHIYNR) MHC Tetramer FCM
MHC-LC4547 PE-DQB1*03:02/Human HLA-DQB1 (TERVRLVTRYIYNREE) MHC Tetramer FCM

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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