PE-DRB1*13:01/Human HLA-B (GPDGRLLRGHDQYAYDGKDY) MHC Tetramer (CAT#: MHC-LC3359)

This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human HLA-B of peptide GPDGRLLRGHDQYAYDGKDY covering 128-147 and DRB1*13:01 molecule. The pMHC tetramer recognizes CD4 T cells, and can be used in the analysis of individual antigen-specific T cells.


Specific Inquiry
  • Size:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Normal Tissue
RNA Expression

Specifications

  • Allele
  • DRB1*13:01
  • Class
  • Class II
  • Antigen
  • HLA-B
  • Antigen Species
  • Human
  • Peptide
  • GPDGRLLRGHDQYAYDGKDY
  • Range
  • 128-147
  • Conjugate
  • PE
  • Application
  • FCM

Target

  • Antigen Introduction
  • HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008]
  • Alternative Names
  • HLA-B; HLA class I histocompatibility antigen, B-7 alpha chain precursor; AS; HLAB; B-4901

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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