Pancrelipase (CAT#: TP-024CL)
Pancrelipase is an enzyme mixture isolated from porcine or bovine pancreas, sometimes called pancreatin. It contains 3 enzymes: amylase, lipase, and a protease (chymotrypsin). Pancrelipase is marketed under several brand names such as Ultresa™ and Viokace™.
Normal Tissue
Figure 1 IHC staining of human pancreas
(Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in exocrine glandular cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45394/ihc_selected.jpg
(Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in exocrine glandular cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45394/ihc_selected.jpg
Figure 2 High expression in pancreas.
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45960/119580_A_2_3_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45960/119580_A_2_3_val_selected.jpg
Figure 3 Low expression in liver.
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45960/119580_A_7_4_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45960/119580_A_7_4_val_selected.jpg
Figure 4 Pancreas
(Exocrine glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45399/119582_A_2_3.jpg
(Exocrine glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45399/119582_A_2_3.jpg
Specifications
- Classify
- Protein therapeutics replacing a protein that is deficient or abnormal: Pulmonary and gastrointestinal-tract disorders
- Therapeutic
- Pancreatic enzymes (lipase, amylase, protease)
- Trade Name
- Arco-Lase, Cotazym, Creon, Donnazyme, Pancrease, Viokase, Zymase
- Function
- Digests food (protein, fat and carbohydrate); purified from hogs and pigs
- Examples of clinical use
- Cystic fibrosis, chronic pancreatitis, pancreatic insufficiency, post-Billroth ii gastric bypass surgery, pancreatic duct obstruction, steatorrhoea, poor digestion, gas, bloating
References
- Synonyms
- 1,4-alpha-D- glucan glucanohydrolase, PA, Pancreatic alpha-amylase precursor, Pancrelipase (amylase;lipase;protease)
- UniProt
- P04746
- Genbank
- M18785
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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