Products

Peginterferon alfa-2b (TP-041CL)

Peginterferon alfa-2b is a covalent conjugate of recombinant alfa-2b interferon with monomethoxy polyethylene glycol (PEG). The average molecular weight of the PEG portion of the molecule is 12,000 daltons. The average molecular weight of the PEG-Intron molecule is approximately 31,000 daltons. The specific activity of peginterferon alfa-2b is approximately 0.7 × 108 IU/mg protein. Interferon alfa-2b is a water-soluble protein with a molecular weight of 19,271 daltons produced by recombinant DNA techniques. It is obtained from the bacterial fermentation of a strain of Escherichia coli bearing a genetically engineered plasmid containing an interferon gene from human leukocytes. The PEG strand protects the molecule in vivo from proteolytic breakdown, substantially increases its in vivo half-life, and reduces immunogenicity by wrapping around and physically hindering access to the protein portion of the molecule.      

Specifications
Classify
Protein therapeutics augmenting an existing pathway: Immunoregulation
Therapeutic
Peginterferon-α2b
Trade Name
Peg-Intron
Function
Recombinant interferon-a2b conjugated to polyethylene glycol (PeG) to increase half-life
Examples of Clinical Use
Adults with chronic hepatitis c who have compensated liver disease and who have not been treated previously with iFNa
References
Synonyms
Not Available
UniProt
P01563

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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