Products

Pegvisomant (TP-101CL)

Pegvisomant is a highly selective growth hormone (GH) receptor antagonist. It is used to treat acromegaly. Unlike dopamine or somatostatin analogs (which inhibit growth hormone secretion), this drug actually blocks the hepatic (GH-mediated) production of insulin like growth factor (IGF-1), which is the main mediator of growth hormone activity.      

Specifications
Classify
Protein therapeutics that interfere with a molecule or organism: Endocrine disorders
Therapeutic
Pegvisomant
Trade Name
Somavert
Function
Recombinant human growth hormone conjugated to PeG; blocks the growth hormone receptor
Examples of Clinical Use
Acromegaly
References
Synonyms
GH, GH-N, Growth hormone, Growth hormone 1, Pituitary growth hormone, Somatotropin precursor
UniProt
P58756
Genbank
AF374232

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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