Protein A-MCC-DM1 ADC (CAT#: ADC-186LCT)

This ADC product is composed of Protein A conjuagated via a mcc linker to DM1 (Protein A-MCC-DM1). It has demonstrated a response in cancer treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.


Specific Inquiry
  • Datasheet
  • MSDS
  • COA

Specifications

  • Clone
  • Protein A
  • Linker
  • mcc (Maleimidomethyl cyclohexane-1-carboxylate)
  • Linker Class/Description
  • Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.
  • Drug
  • DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
  • Drug Class/Description
  • Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
    macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells

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Recombinant Antibody

CAT Product Name Application Type
MOB-811 Recombinant Anti-Protein A Antibody ELISA, WB, FuncS IgG
MHH-811 Recombinant Human Anti-Protein A Antibody ELISA, WB, IF, FuncS IgG
HPAB-0403-YJ Recombinant Chimeric (Human/Mouse) Anti-Protein A Antibody (7D2) ELISA Chimeric (Human/Mouse) IgG1, κ

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0662MZ Chicken Anti-Protein A Polyclonal IgY N/A Chicken antibody
BRD-0815MZ Chicken Anti-Protein A Polyclonal IgY, HRP ELISA, WB Chicken antibody
BRD-0819MZ Chicken Anti-Protein A Polyclonal IgY ELISA, WB Chicken antibody

Single-domain Antibody

CAT Product Name Application Type
HPAB-AP910-YC Recombinant Human Anti-Protein A Single Domain Antibody (HVHP428) FC, MA Human VHH

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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