This immunotoxin was achieved by conjugating/fusing the RAP to Diphtheriatoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to Glioma cells. Once bind, the toxin enters cells by receptor-mediated endocytosis, then Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme; -II binding and elongation factor into the eukaryotic cell; the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs; thereby preventing protein synthesis and causes cell death. It was designed for treatment of Glioma.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-631 | Recombinant Anti-human LRP1 Antibody | ELISA, WB, Dot, FuncS | IgG |
MHH-631 | Recombinant Human Anti-human LRP1 Antibody | WB, RIA, FuncS | IgG |
MRO-0939-CN | Recombinant Rabbit Anti-LRP1 Monoclonal Antibody (CBACN-347) | WB, IF, IHC, IP, FC | Rabbit IgG |
MRO-0940-CN | Recombinant Mouse Anti-LRP1 Monoclonal Antibody (A4-F5) | WB, IHC | Mouse IgG2a |
VS3-FY859 | Recombinant Rabbit Anti-LRP1 Antibody (clone R09-4E8) | WB, IHC-Fr, IHC-P, ICC, IF, IP | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-631-F(E) | Recombinant Anti-human LRP1 Antibody Fab Fragment | IF, Neut, FuncS | Fab |
MHH-631-F(E) | Recombinant Human Anti-human LRP1 Antibody Fab Fragment | ELISA, WB, IF, FuncS | Fab |
HPAB-N0364-YC-F(E) | Human Anti-LRP1 Recombinant Antibody; Fab Fragment (HPAB-N0364-YC-F(E)) | WB, FuncS | Human Fab |
HPAB-N0365-YC-F(E) | Human Anti-LRP1 Recombinant Antibody; Fab Fragment (HPAB-N0365-YC-F(E)) | WB, FuncS | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-631-S(P) | Recombinant Anti-human LRP1 Antibody scFv Fragment | FC, IP, FuncS | scFv |
MHH-631-S(P) | Recombinant Human Anti-human LRP1 Antibody scFv Fragment | FC, Neut, Funcs | scFv |
HPAB-N0364-YC-S(P) | Human Anti-LRP1 Recombinant Antibody; scFv Fragment (HPAB-N0364-YC-S(P)) | WB, FuncS | Human scFv |
HPAB-N0365-YC-S(P) | Human Anti-LRP1 Recombinant Antibody; scFv Fragment (HPAB-N0365-YC-S(P)) | WB, FuncS | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-L081E | RAP-PE immunotoxin | Cytotoxicity assay, Functional assay |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1701CQ | Recombinant Mouse Anti-LRP1 Antibody (8G1) | BL, FC, ICC/IF, IHC-Fr, IHC-P, WB | IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-2084 | Hi-Affi™ Recombinant Rabbit Anti-LRP1 Monoclonal Antibody (DS2084AB) | IHC-P, WB, IP, ICC/IF | IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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