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Rasburicase (TP-073CL)

Rasburicase is a recombinant urate-oxidase enzyme produced by a genetically modified Saccharomyces cerevisiae strain. The cDNA coding for rasburicase was cloned from a strain of Aspergillus flavus.      

Specifications
Classify
Protein therapeutics providing a novel function or activity: Enzymatic degradation of small-molecule metabolites
Therapeutic
Rasburicase
Trade Name
Elitek
Function
Catalyzes enzymatic oxidation of uric acid into an inactive, soluble metabolite (allantoin); originally isolated from Aspergillus flavus
Examples of Clinical Use
Paediatric patients with leukaemia, lymphoma, and solid tumours who are undergoing anticancer therapy that may cause tumour lysis syndrome
References
Synonyms
Urate oxidase, Uricase
UniProt
Q00511
Genbank
X61766

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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