Recombinant Anti-Human CD4 Antibody (Fab glycosylation) (CAT#: Gly-025LC)
This product is a humanized monoclonal antibody with N-glycosylation site Asn-Ser-Thr in the light chain. The glyco-engineered antibody LM52 of higher neutralization activity specifically binds human CD4 and can be potentially used in the treatment of HIV.
Specific Inquiry
Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11/if_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11/if_selected.jpg
Figure 2 RNA cell line category: Group enriched (HEL, HL-60, NB-4, THP-1, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000010610-CD4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000010610-CD4
Figure 2 RNA cell line category: Group enriched (HEL, HL-60, NB-4, THP-1, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000010610-CD4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000010610-CD4
Glyco-engineering
- Glycosylation site
- Asn-Ser-Thr in light chain
- Glycoform (ratio)
- Gal3NAc4F1 (NNH3NNF1) (~8%)
Gal3NAc5F1 (NNNH3NNF1) (~29%)
Gal4NAc5F1 (HNNNH3NNF1) (~24%)
- Glycosylation Type
- N-glycosylation
- Activity
- Higher neutralization activities
Specifications
- Target
- CD4 (Cluster of differentiation-4)
- Host Species
- Human
- Derivation
- Humanized
- Type
- Humanized antibody
- Specificity
- Human
- Clone
- LM52
- Expression Host
- 293A
- Applications
- ELISA
Target
- Alternative Names
- CD4; CD4 molecule; CD4mut; T-cell surface glycoprotein CD4; CD4 receptor; CD4 antigen (p55); T-cell surface antigen T4/Leu-3
- Related Disease
- HIV
- Gene ID
- 920
- UniProt ID
- B4DT49
Related Resources
Primary Immunodeficiency
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "CD4"
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-039 | Anti-Human CD4 Recombinant Antibody (Zanolimumab) | Neut, ELISA, IF, IP, FuncS, FC, IHC | IgG1 - kappa |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-164 | Anti-Human CD4 Recombinant Antibody (Priliximab) | WB, FuncS, IF, Neut, ELISA, FC, IP | IgG1 - kappa |
| TAB-171 | Anti-Human CD4 Recombinant Antibody (Keliximab) | FuncS, IF, Neut, ELISA, FC, IP, ICC | IgG1 - lambda |
| TAB-732 | Anti-CD4 Recombinant Antibody (Clenoliximab) | IF, IP, Neut, FuncS, ELISA, FC, ICC | IgG4 - lambda |
| TAB-167LC-S(P) | Anti-Human CD4 Recombinant Antibody scFv Fragment (cM-T412) | ELISA | Chimeric antibody (mouse/human) |
| TAB-170LC-S(P) | Rat Anti-CD4 Recombinant Antibody; scFv Fragment (TAB-170LC-S(P)) | ELISA, SPR | Rat scFv |
Immunotoxin
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G078E | Anti-CD4 immunotoxin M-T151 (IgG)-PE | Cytotoxicity assay, Function study | |
| AGTO-G078R | Anti-CD4 immunotoxin M-T151 (IgG)-RTA | Cytotoxicity assay, Function study |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-160LC | Anti-Human CD4 Recombinant Antibody (OKT4A) | ELISA, WB | |
| TAB-166LC | Anti-Human CD4 Recombinant Antibody (M-T412) | ELISA, Inhib | |
| TAB-173LC | Anti-Human CD4 Recombinant Antibody (IgA F425-Alg8) | ELISA, Inhib | |
| TAB-174LC | Mouse Anti-CD4 Recombinant Antibody (TAB-174LC) | ELISA, FC, IHC, Neut, FuncS | Mouse IgG1 |
| TAB-175LC | Anti-Human CD4 Recombinant Antibody (15A7) | ELISA, FC, IF, WB, Inhib |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-161LC | Anti-Human CD4 Recombinant Antibody (gOKT4A-4) | ELISA | Humanized antibody |
| TAB-168LC | Anti-Human CD4 Recombinant Antibody (TRX1) | ELISA | Humanized antibody |
| TAB-171LC | Human Anti-CD4 Recombinant Antibody (TAB-171LC) | ELISA, FC, SPR | Humanized antibody |
| TAB-172LC | Human Anti-CD4 Recombinant Antibody (TAB-172LC) | ELISA, Inhib | Human IgG |
| TAB-161LC-S(P) | Anti-Human CD4 Recombinant Antibody scFv Fragment (gOKT4A-4) | ELISA | Humanized antibody |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-351CQ | Mouse Anti-CD4 Recombinant Antibody (clone 10C12) | ELISA, WB, IF, Block | Mouse IgG1 |
| NEUT-352CQ | Mouse Anti-CD4 Recombinant Antibody (clone 13B8.2) | Block, ELISA, FC, IHC-Fr, WB | Mouse IgG1, κ |
| NEUT-355CQ | Mouse Anti-CD4 Recombinant Antibody (clone RPA-T4) | FC, CyTOF, Block, IHC | Mouse IgG1, κ |
| NEUT-357CQ | Rat Anti-CD4 Recombinant Antibody (clone MAB0810) | Block, Depletion, Stim | Rat IgG2b |
| NEUT-358CQ | Rat Anti-CD4 Recombinant Antibody (clone RM4-5) | FC, CyTOF, Depletion, Block, IHC | Rat IgG2a, κ |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-353CQ | Mouse Anti-CD4 Recombinant Antibody (clone CBL976) | FC, Neut, IF, IHC | Mouse IgG1, κ |
| NEUT-354CQ | Recombinant Mouse Anti-CD4 Antibody (CT-4) | Neut, FC, IHC, IHC-Fr, IHC-P, IP | IgG1, κ |
| NEUT-356CQ | Mouse Anti-CD4 Recombinant Antibody (clone 3-4F4) | Neut, FC, IHC, IHC-Fr, IP, ICC | Mouse IgG1, κ |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0560 | Hi-Affi™ Rabbit Anti-CD4 Recombinant Antibody (clone DS560AB) | IHC-P | Rabbit IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0054YC | Mouse Anti-CD4 Recombinant Antibody (clone M-T310) | Neut | Mouse IgG1, κ |
| FAMAB-0055YC | Mouse Anti-CD4 Recombinant Antibody (clone M-T404) | Neut | Mouse IgG1, κ |
| FAMAB-0056YC | Mouse Anti-CD4 Recombinant Antibody (clone M-T408) | Neut | Mouse IgG1, κ |
| FAMAB-0057YC | Mouse Anti-CD4 Recombinant Antibody (clone M-T151) | Neut | Mouse IgG2a, κ |
| HPAB-0758-CN | Human Anti-CD4 Recombinant Antibody (clone Variant B) | ELISA, FC | Human IgG1 |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0135CQ-F(E) | Human Anti-CD4 Recombinant Antibody; Fab Fragment (HPAB-0135CQ-F(E)) | ELISA, FuncS | Human Fab |
| HPAB-0136CQ-F(E) | Mouse Anti-CD4 Recombinant Antibody; Fab Fragment (HPAB-0136CQ-F(E)) | ELISA, FuncS | Mouse Fab |
| HPAB-0137CQ-F(E) | Mouse Anti-CD4 Recombinant Antibody (clone RIB 5/2); Fab Fragment | IHC, FC | Mouse Fab |
| HPAB-0302LY-F(E) | Human Anti-CD4 Recombinant Antibody (clone TNX-355); Fab Fragment | ELISA | Humanized Fab |
| HPAB-0303LY-F(E) | Human Anti-CD4 Recombinant Antibody (clone G4H); Fab Fragment | ELISA | Humanized Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-039 | Afuco™ Anti-CD4 ADCC Recombinant Antibody (Zanolimumab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| AFC-TAB-164 | Afuco™ Anti-CD4 ADCC Recombinant Antibody (Priliximab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-260 | Afuco™ Anti-CD4 ADCC Recombinant Antibody (Tregalizumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF | ADCC enhanced antibody |
| AFC-TAB-171 | Afuco™ Anti-CD4 ADCC Recombinant Antibody (Keliximab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| AFC-TAB-107 | Afuco™ Anti-CD4 ADCC Recombinant Antibody (Cedelizumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0557-WJ-S(P) | Human Anti-CD4 Recombinant Antibody (clone TRX1); scFv Fragment | ELISA | Human scFv |
| HPAB-0558-WJ-S(P) | Human Anti-CD4 Recombinant Antibody (clone 6G5); scFv Fragment | ELISA | Human scFv |
| HPAB-0957WJ-S(P) | Human Anti-CD4 Recombinant Antibody (clone 4-91); scFv Fragment | ELISA | Human scFv |
| HPAB-J0053-YC-S(P) | Human Anti-CD4 Recombinant Antibody; scFv Fragment (HPAB-J0053-YC-S(P)) | ELISA, FC | Humanized (rat/human) scFv |
| HPAB-2112-FY-S(P) | Mouse Anti-CD4 Recombinant Antibody (clone MT15.1); scFv Fragment | Inhib | Mouse scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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