Recombinant Human Anti-YFV E Antibody scFv Fragment (CAT#: DrMAB-936)

Figure 1 Binding of mAb 5A against YFV.

BIAcore diagram of 5A bound to YFV-17D sE protein. 5A binds to the YFV-17D sE protein with high affinity and slow kinetics.

Lu, X., Xiao, H., Li, S., Pang, X., Song, J., Liu, S., ... & Guo, T. (2019). Double lock of a human neutralizing and protective monoclonal antibody targeting the yellow fever virus envelope. Cell reports, 26(2), 438-446.

Figure 2 Neutralization of mAb 5A against YFV.

YFV-17D amplified in Vero cells was mixed with threefold serial dilutions of the indicated mAbs, and neutralization activity was then evaluated by a FACSbased neutralization assay using Vero cells.

Lu, X., Xiao, H., Li, S., Pang, X., Song, J., Liu, S., ... & Guo, T. (2019). Double lock of a human neutralizing and protective monoclonal antibody targeting the yellow fever virus envelope. Cell reports, 26(2), 438-446.

Figure 3 Neutralization activity of the indicated mAbs against YFV-China.

Lu, X., Xiao, H., Li, S., Pang, X., Song, J., Liu, S., ... & Guo, T. (2019). Double lock of a human neutralizing and protective monoclonal antibody targeting the yellow fever virus envelope. Cell reports, 26(2), 438-446.

Figure 4 Protection of mAb 5A against YFV.

Therapeutic effect of mAb 5A against YFV-17 lethal challenge.

Lu, X., Xiao, H., Li, S., Pang, X., Song, J., Liu, S., ... & Guo, T. (2019). Double lock of a human neutralizing and protective monoclonal antibody targeting the yellow fever virus envelope. Cell reports, 26(2), 438-446.

Figure 5 Body weight was recorded daily. Survival and body-weight-loss curves are plotted using GraphPad Prism 5.

mAb 5A shows significant protection of against YFV.

Lu, X., Xiao, H., Li, S., Pang, X., Song, J., Liu, S., ... & Guo, T. (2019). Double lock of a human neutralizing and protective monoclonal antibody targeting the yellow fever virus envelope. Cell reports, 26(2), 438-446.