Mouse Anti-Tgfb1 Recombinant Antibody (clone CB57B9) (CAT#: DrMAB-98)

Figure 1 Neutralization of TGF-b in vivo.

EAE mice were given i.p. 0.4 mg of mouse IgG (open diamonds) or 0.4 mg of anti-TGF-b neutralizing antibody (filled squares) on days 24, 26, 28 and 30 after induction of EAE.

Zhang, X., Reddy, J., Ochi, H., Frenkel, D., Kuchroo, V. K., & Weiner, H. L. (2006). Recovery from experimental allergic encephalomyelitis is TGF-β dependent and associated with increases in CD4+ LAP+ and CD4+ CD25+ T cells. International immunology, 18(4), 495-503.

Figure 2 Overexpression of TGF-β1 from T cells leads to a larger population of TCRαβ+CD8αα+ IELs.

Frequency of CD8αβ⁺ or CD8αα⁺ TCRαβ⁺ IELs in the β1glo⁺Cd4⁻Cre⁺ mice (n = 7) and control littermates.

Konkel, J. E., Maruyama, T., Carpenter, A. C., Xiong, Y., Zamarron, B. F., Hall, B. E., ... & Chen, W. (2011). Control of the development of CD8αα+ intestinal intraepithelial lymphocytes by TGF-β. Nature immunology, 12(4), 312.

Figure 3 TGF-β-deficient mice have a smaller population of DN TCRαβ+CD5+ thymocytes.

Frequency (left) and total number (middle) of DN TCRαβ⁺CD5⁺thymocytes, and frequency of all DN thymocytes (right), in Tgfb1⁻/⁻ mice (n = 14) and their wild-type control littermates (n = 12).

Konkel, J. E., Maruyama, T., Carpenter, A. C., Xiong, Y., Zamarron, B. F., Hall, B. E., ... & Chen, W. (2011). Control of the development of CD8αα+ intestinal intraepithelial lymphocytes by TGF-β. Nature immunology, 12(4), 312.