Anti-HIV-1 antibody is a Human of Fab class that binds to an HIV-1. This antibody neutralizes a broad range of HIV-1 isolates.
Figure 1 Processing of anti-HIV-2 mAbs by N. benthamiana PLCPs.
mAb 2F5 or 2G12 (200 ng) was incubated with NbALP (50 ng), NbCathB (51 ng) or with no enzyme added (control) for the indicated times and then analysed by immunoblotting with antibodies to the heavy chain of human IgG. The migration positions of selected m
Niemer, M., Mehofer, U., Verdianz, M., Porodko, A., Schähs, P., Kracher, D., ... & Mach, L. (2016). Nicotiana benthamiana cathepsin B displays distinct enzymatic features which differ from its human relative and aleurain-like protease. Biochimie, 122, 119-125.
Figure 2 Staining of 2G12 mAb and 9205 mAb on MT-4 cells 4 days after infection with HIV-1 strain NL4.4, HE, MN, and NDK.
MFI of the background fluorescence (blue histograms), for the 2G12 mAb binding (red histograms) and for the 9206 mAb binding (green histograms) are indicated.
Huskens, D., Van Laethem, K., Vermeire, K., Balzarini, J., & Schols, D. (2007). Resistance of HIV-1 to the broadly HIV-1-neutralizing, anti-carbohydrate antibody 2G12. Virology, 360(2), 294-304.
Figure 3 Ribbon diagrams showing the N-glycosylation site mutations (red balls) in gp120 of 2G12 mAb-exposed HIV-1 strains (left panel, 3 mutations) and the mannose-binding plant lectin-exposed HIV-1 strains (right panel, 15 mutations).
The left panel shows the 24 putative glycosylation sites represented by yellow circles and their accompanying amino acid number. The red circles indicate the deleted N-glycosylation sites that appear under 2G12 mAb in the 4 different HIV-2 isolates.
The rȔ
Huskens, D., Van Laethem, K., Vermeire, K., Balzarini, J., & Schols, D. (2007). Resistance of HIV-1 to the broadly HIV-1-neutralizing, anti-carbohydrate antibody 2G12. Virology, 360(2), 294-304.
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CAT | Product Name | Application | Type |
---|---|---|---|
NAB-1889-sdAb | Recombinant Anti-HIV-1 VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
PNBL-038 | Recombinant Anti-HIV-1 C186 gp120 VHH Single Domain Antibody (A12) | WB, FuncS | Llama VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-068 | Anti-HIV-1 Recombinant Antibody (Suvizumab) | WB, ELISA, IP, FC, FuncS, Neut, IF | IgG1 - kappa |
PABX-094-S (P) | Recombinant Human Anti-HIV-1 Antibody scFv Fragment (Fab4025) | WB, ELISA, FuncS | scFv |
PABX-099-S (P) | Recombinant Human Anti-HIV-1 Antibody scFv Fragment | FC, FuncS | scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-G037E | Anti-HIV-1 immunotoxin 3B3 (scFv)-PE | Cytotoxicity assay, Function study | |
AGTO-G037D | Anti-HIV-1 immunotoxin 3B3 (scFv)-DT | Cytotoxicity assay, Function study |
CAT | Product Name | Application | Type |
---|---|---|---|
PABL-140 | Human Anti-HIV-1 Recombinant Antibody (clone VRC26.25) | WB, ELISA, Neut, FuncS | Human IgG1 |
MRO-770CQ | Mouse Anti-HIV-1 Recombinant Antibody (clone 10 (03-002)) | EIA, WB, IHC, IP | Mouse IgG1 |
MRO-771CQ | Mouse Anti-HIV-1 Recombinant Antibody (clone 1-B-388) | ELISA, WB | Mouse IgG1 |
MRO-772CQ | Mouse Anti-HIV-1 Recombinant Antibody (clone 1-B-392) | WB | Mouse IgG1 |
MRO-773CQ | Mouse Anti-HIV-1 Recombinant Antibody (clone 340) | ELISA, EIA, WB | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBL-140 | Human Anti-HIV-1 Recombinant Antibody (clone VRC26.25); scFv Fragment | WB, ELISA, Neut, FuncS | Human scFv |
HPAB-0158-YJ-S(P) | Mouse Anti-HIV-1 Recombinant Antibody; scFv Fragment (HPAB-0158-YJ-S(P)) | ELISA, Neut, Inhib | Mouse scFv |
HPAB-AP363-YC-S(P) | Human Anti-HIV-1 Recombinant Antibody (clone A2); scFv Fragment | ELISA, Neut | Human scFv |
HPAB-1988-FY-S(P) | Human Anti-HIV-1 Recombinant Antibody (clone 2G9); scFv Fragment | FC, ELISA | Human scFv |
HPAB-1989-FY-S(P) | Human Anti-HIV-1 Recombinant Antibody (clone 9F11); scFv Fragment | FC, ELISA | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-140 | Human Anti-HIV-1 Recombinant Antibody (clone VRC26.25); Fab Fragment | WB, ELISA, Neut, FuncS | Human Fab |
FAMAB-0176CQ-F(E) | Mouse Anti-HIV-1 Recombinant Antibody (clone KEL10); Fab Fragment | ELISA, Neut | Mouse Fab |
HPAB-0158-YJ-F(E) | Human Anti-HIV-1 Recombinant Antibody; Fab Fragment (HPAB-0158-YJ-F(E)) | ELISA, Neut, Inhib | Human Fab |
HPAB-AP363-YC-F(E) | Human Anti-HIV-1 Recombinant Antibody (clone A2); Fab Fragment | ELISA, Neut | Human Fab |
HPAB-1988-FY-F(E) | Human Anti-HIV-1 Recombinant Antibody (clone 2G9); Fab Fragment | FC, ELISA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-084 | Recombinant Mouse Anti-HIV-1 Antibody (83.1) | WB, ELISA, FuncS | IgG |
PABX-089 | Recombinant Mouse Anti-HIV-1 Antibody (A10F9) | Neut, FuncS | IgG |
PABX-093 | Recombinant Mouse Anti-HIV-1 Antibody (Fab28) | WB, ELISA, FuncS | IgG |
PABX-095 | Recombinant Mouse Anti-HIV-1 Antibody (Fab59.1) | Neut, ELISA, FuncS | IgG |
PABX-096-S (P) | Recombinant Human Anti-HIV-1 Antibody scFv Fragment (N12-i15) | WB, ELISA, IF, FuncS | scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-090 | Recombinant Human Anti-HIV-1 Antibody (CH04H/CH02L) | Neut, FuncS | IgG |
PABX-091 | Recombinant Human Anti-HIV-1 Antibody (Fab2219) | Neut, ELISA, FuncS | IgG |
PABX-092 | Recombinant Human Anti-HIV-1 Antibody (Fab2558) | WB, ELISA, Neut, FuncS | IgG |
PABX-094 | Recombinant Human Anti-HIV-1 Antibody (Fab4025) | WB, ELISA, FuncS | IgG |
PABX-096 | Recombinant Human Anti-HIV-1 Antibody (N12-i15) | WB, ELISA, IF, FuncS | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-093-S (P) | Recombinant Mouse Anti-HIV-1 Antibody scFv Fragment (Fab28) | WB, ELISA, FuncS | scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-LC1376 | PE-A*02:01/HIV-1 (SLFNTVATL) MHC Tetramer | FCM | |
MHC-LC1377 | APC-A*02:01/HIV-1 (SLFNTVATL) MHC Tetramer | FCM | |
MHC-LC1378 | BV421-A*02:01/HIV-1 (SLFNTVATL) MHC Tetramer | FCM |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-4221 | Rabbit Anti-HIV-1 Recombinant Antibody (clone SI300DS) | ELISA, ICC, IF, FC | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-068 | Afuco™ Anti-HIV-1 ADCC Recombinant Antibody (Suvizumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut | ADCC enhanced antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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