Recombinant Mouse Anti-PrP Antibody Fab Fragment (POM1) (CAT#: PABX-161-F (E))

Figure 1 Epitope specificity of the neurotoxicity mediated by antiprion antibodies.

Antibody binding sites on PrP(23–230). POM6–9, 13, 15 and 17 bind helix a1 and compete with POM1 (ref. 3). POM6 and POM7 (light orange) show additional binding sites at helix a2 (drk orange), whereas POM5 recognizes a unique epitope at the b2–a2 transition (green, Supplementary Table 2). The GD image was rendered using the PDB structure 2L1H.

Sonati, T., Reimann, R. R., Falsig, J., Baral, P. K., O’connor, T., Hornemann, S., ... & Swayampakula, M. (2013). The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein. Nature, 501(7465), 102.

Figure 2 In vivo toxicity of antibodies binding to PrP.

Manganeseenhanced magnetic resonance imaging (MEMRI) scans showed hypointense lesions in POM1-treated (6 mg in 2ml) wild-type (WT) and tga20 mice (left panels) 72 h post intracerebellar injection.

Sonati, T., Reimann, R. R., Falsig, J., Baral, P. K., O’connor, T., Hornemann, S., ... & Swayampakula, M. (2013). The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein. Nature, 501(7465), 102.