Products

Reteplase (TP-048CL)

Human tissue plasminogen activator, purified, glycosylated, 355 residues purified from CHO cells. Retavase is considered a "third-generation" thrombolytic agent, genetically engineered to retain and delete certain portions of human tPA. Retavase is a deletion mutein of human tPA formed by deleting various amino acids present in endogenous human tPA. Retavase contains 355 of the 527 amino acids of native human tPA (amino acids 1-3 and 176-527), and retains the activity-related kringle-2 and serine protease domains of human tPA. Three domains are deleted from retavase – kringle-1, finger, and epidermal growth factor (EGF).      

Specifications
Classify
Protein therapeutics augmenting an existing pathway: Haemostasis and thrombosis
Therapeutic
Reteplase (deletion mutein of tPA)
Trade Name
Retavase
Function
Contains the non-glycosylated kringle 2 and protease domains of human tPA; functions similarly to tPA
Examples of Clinical Use
Management of acute myocardial infarction, improvement of ventricular function
References
Synonyms
t- PA, t-plasminogen activator, Tissue-type plasminogen activator precursor, tPA
UniProt
P00750
Genbank
L00153

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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