Reteplase (CAT#: TP-048CL)
Human tissue plasminogen activator, purified, glycosylated, 355 residues purified from CHO cells. Retavase is considered a "third-generation" thrombolytic agent, genetically engineered to retain and delete certain portions of human tPA. Retavase is a deletion mutein of human tPA formed by deleting various amino acids present in endogenous human tPA. Retavase contains 355 of the 527 amino acids of native human tPA (amino acids 1-3 and 176-527), and retains the activity-related kringle-2 and serine protease domains of human tPA. Three domains are deleted from retavase – kringle-1, finger, and epidermal growth factor (EGF).
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to actin filaments.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3412/if_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to actin filaments.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3412/if_selected.jpg
Figure 2 IHC staining of human duodenum
(Immunohistochemical staining of human duodenum shows strong positivity in plasma.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3412/ihc_selected.jpg
(Immunohistochemical staining of human duodenum shows strong positivity in plasma.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3412/ihc_selected.jpg
Figure 3 Cerebral cortex
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3412/11857_B_8_5.jpg
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3412/11857_B_8_5.jpg
Figure 4 Liver
(Hepatocytes
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3412/11857_A_9_4.jpg
(Hepatocytes
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3412/11857_A_9_4.jpg
Figure 5 Kidney
(Cells in tubules
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3412/11857_A_9_5.jpg
(Cells in tubules
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3412/11857_A_9_5.jpg
Figure 6 Lymph node
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3412/11857_A_9_8.jpg
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3412/11857_A_9_8.jpg
Figure 7 RNA cell line category: Cell line enhanced (CAPAN-2, HMC-1, hTERT-RPE1, LHCN-M2, U-2197, WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000104368-PLAT/subcellular
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000104368-PLAT/subcellular
Specifications
- Classify
- Protein therapeutics augmenting an existing pathway: Haemostasis and thrombosis
- Therapeutic
- Reteplase (deletion mutein of tPA)
- Trade Name
- Retavase
- Function
- Contains the non-glycosylated kringle 2 and protease domains of human tPA; functions similarly to tPA
- Examples of clinical use
- Management of acute myocardial infarction, improvement of ventricular function
References
- Synonyms
- t- PA, t-plasminogen activator, Tissue-type plasminogen activator precursor, tPA
- UniProt
- P00750
- Genbank
- L00153
Downloads
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2092CT | Recombinant Mouse anti-Human PLAT Monoclonal antibody (3B264) | IHC-FoFr, WB | |
| MRO-1500-CN | Recombinant Rabbit Anti-PLAT Monoclonal Antibody (JF0958) | WB, IHC | Rabbit IgG |
| VS3-QX885 | Mouse Anti-PLAT Recombinant Antibody (clone AH54-10) | ELISA, WB, ICC, IHC | Mouse IgG1 |
| VS3-QX886 | Mouse Anti-PLAT Recombinant Antibody (clone AH81-00) | ELISA, WB, ICC, IHC | Mouse IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2735 | Hi-Affi™ Recombinant Rabbit Anti-PLAT Monoclonal Antibody (DS2735AB) | ELISA, WB | IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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