Recombinant monoclonal antibody to RSPO3. Rosmantuzumab is a humanized monoclonal antibody that can be potentially used in the treatment of Advanced Relapsed Tumor, Refractory Solid Tumors.
Figure 1 CRC with PTPRK-RSPO3 fusions respond to RSPO3-taxane treatment.
(A) VACO6 cell line is responsive to irinotecan and nab-paclitaxel when combined with RSPO3 neutralizing antibody anti-Rspo3. (B) SNU1411 is non-responsive to anti-Rspo3, irinotecan, or anti-Rspo3 + irinotecan. SNU1411 can be sensitized to nab-paclitaxel when combined with anti-Rspo3. Anti-Rspo3 was dosed at 25 mpk Q2W on day 1, irinotecan was dosed at 10 mpk Q1W on days 3 and 10, and nab-paclitaxel was dosed at 25 mpk Q2W on day 3, 7–10 mice per treatment group. *p < 0.01 vs. nab-paclitaxel, **p < 0.001 vs. nab-paclitaxel, ns = not significant.
Fischer, M. M., Yeung, V. P., Cattaruzza, F., Hussein, R., Yen, W. C., Murriel, C., ... & Cain, J. (2017). RSPO3 antagonism inhibits growth and tumorigenicity in colorectal tumors harboring common Wnt pathway mutations. Scientific reports, 7(1), 15270.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Afuco™ Anti-RSPO3 ADCC Recombinant Antibody (Rosmantuzumab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to RSPO3. Rosmantuzumab is a humanized monoclonal antibody that can be potentially used in the treatment of Advanced Relapsed Tumor, Refractory Solid Tumors.
CAT | Product Name | Application | Type |
---|---|---|---|
NAB-2146-VHH | Recombinant Anti-Human RSPO3 VHH Single Domain Antibody | IHC, IP, FC, Neut, FUNC | Llama VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-351CT | Humanized Anti-RSPO3 Recombinant Antibody (TAB-351CT) | WB, ELISA, Neut, FC, IHC, IP | Humanized IgG |
TAB-351CT-S(P) | Humanized Anti-RSPO3 Recombinant Antibody; scFv Fragment (TAB-351CT-S(P)) | WB, ELISA, Neut, FC, IHC, IP | Humanized scFv |
TAB-351CT-F(E) | Humanized Anti-RSPO3 Recombinant Antibody; Fab Fragment (TAB-351CT-F(E)) | WB, ELISA, Neut, FC, IHC, IP | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-350CT-F(E) | Mouse Anti-RSPO3 Recombinant Antibody; Fab Fragment (TAB-350CT-F(E)) | WB, ELISA, Neut, FC, IHC, IP | Mouse Fab |
TAB-352CT-F(E) | Mouse Anti-RSPO3 Recombinant Antibody; Fab Fragment (TAB-352CT-F(E)) | WB, ELISA, Neut, FC, IHC, IP | Mouse Fab |
TAB-353CT-F(E) | Mouse Anti-RSPO3 Recombinant Antibody; Fab Fragment (TAB-353CT-F(E)) | WB, ELISA, Neut, FC, IHC, IP | Mouse Fab |
TAB-354CT-F(E) | Mouse Anti-RSPO3 Recombinant Antibody; Fab Fragment (TAB-354CT-F(E)) | WB, ELISA, Neut, FC, IHC, IP | Mouse Fab |
TAB-355CT-F(E) | Mouse Anti-RSPO3 Recombinant Antibody; Fab Fragment (TAB-355CT-F(E)) | WB, ELISA, Neut, FC, IHC, IP | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0036CQ | Human Anti-RSPO3 Recombinant Antibody (clone h131R008) | ELISA, Inhib | Humanized IgG1, κ |
HPAB-0037CQ | Human Anti-RSPO3 Recombinant Antibody (clone h131R007) | ELISA, Inhib, FC | Humanized IgG2, κ |
HPAB-0038CQ | Mouse Anti-RSPO3 Recombinant Antibody (clone 131R003) | ELISA, Inhib | Mouse IgG2, κ |
HPAB-M0618-YC | Rat Anti-RSPO3 Recombinant Antibody (clone 4A6) | ELISA | Rat IgG2a |
HPAB-M0619-YC | Rat Anti-RSPO3 Recombinant Antibody (clone 11C10) | ELISA | Rat IgG2 |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-M0618-YC-S(P) | Rat Anti-RSPO3 Recombinant Antibody (clone 4A6); scFv Fragment | ELISA | Rat scFv |
HPAB-M0619-YC-S(P) | Rat Anti-RSPO3 Recombinant Antibody (clone 11C10); scFv Fragment | ELISA | Rat scFv |
HPAB-M0620-YC-S(P) | Rat Anti-RSPO3 Recombinant Antibody (clone 15F3); scFv Fragment | ELISA | Rat scFv |
HPAB-M0621-YC-S(P) | Human Anti-RSPO3 Recombinant Antibody (clone hu4A6.L4H2); scFv Fragment | ELISA, FuncS | Human scFv |
HPAB-M0622-YC-S(P) | Human Anti-RSPO3 Recombinant Antibody (clone hu11C10.L5H2); scFv Fragment | ELISA, FuncS | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-M0618-YC-F(E) | Rat Anti-RSPO3 Recombinant Antibody (clone 4A6); Fab Fragment | ELISA | Rat Fab |
HPAB-M0619-YC-F(E) | Rat Anti-RSPO3 Recombinant Antibody (clone 11C10); Fab Fragment | ELISA | Rat Fab |
HPAB-M0620-YC-F(E) | Rat Anti-RSPO3 Recombinant Antibody (clone 15F3); Fab Fragment | ELISA | Rat Fab |
HPAB-M0621-YC-F(E) | Human Anti-RSPO3 Recombinant Antibody (clone hu4A6.L4H2); Fab Fragment | ELISA, FuncS | Human Fab |
HPAB-M0622-YC-F(E) | Human Anti-RSPO3 Recombinant Antibody (clone hu11C10.L5H2); Fab Fragment | ELISA, FuncS | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-449CQ | Afuco™ Anti-RSPO3 ADCC Recombinant Antibody (Rosmantuzumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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