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SH3 domain anti-ABL1 (SST-L186)

The SH3 domain that bound SH3 domain of the Abelson tyrosine kinase (Abl-SH3). was isolated from the library using Phage display techonology. After affinity maturation, SH3 domain variants were identified having affinities (KD=90 μM) for SH3 domain of the Abelson tyrosine kinase (Abl-SH3). as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.      

Specifications
Scaffold Name
SH3 domain
Origin
Avian pancreatic polypeptide
Core Structure
α/ppII helix (36)
Variable Regions
5 aa randomized or rational design
Target
SH3 domain of the Abelson tyrosine kinase (Abl-SH3).
Species Reactivity
Human
Expression Host
E. coli
Affinity Constant
90 μM
Applications
ELISA; IHC; Microscopy; FC; WB; FuncS
Target
Alternative Names
Avian pancreatic polypeptide; SH3 domain; ABL; JTK7; p150; c-ABL; v-abl; c-ABL1
Entrez Gene ID
25
UniProt ID
P00519

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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