Anti-EDA (F8)-SS-DM1 ADC (CAT#: ADC-114LCT)
This ADC product is composed of an anti-extra domains A (EDA) antibody (clone F8) conjuagated via a Disulfide-linker to e thiol-containing maytansinoid DM1 (SIP(F8)-SS-DM1). It has demonstrated a response in treatment by a MOA (Mechanism of Action) of cytotoxic.
Specific Inquiry
Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line HEK 293
(Immunofluorescent staining of human cell line HEK 293 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37972/if_selected.jpg
(Immunofluorescent staining of human cell line HEK 293 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37972/if_selected.jpg
Figure 2 IF staining of human cell line Hep G2
(Immunofluorescent staining of human cell line Hep G2 shows localization to lipid droplets.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37973/763_F5_2_selected.jpg
(Immunofluorescent staining of human cell line Hep G2 shows localization to lipid droplets.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37973/763_F5_2_selected.jpg
Figure 3 RNA cell line category: Cell line enhanced (EFO-21, Hep G2, OE19, RPMI-8226)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000158813-EDA
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000158813-EDA
Specifications
- Clone
- F8
- Linker
- Disulfide-linker
- Linker Class/Description
- Disulfide Linkers are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.
- Drug
- DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
- Drug Class/Description
- Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells
Target
- Introduction
- The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Alternative Names
- EDA; ectodysplasin A; ED1; HED; EDA1; EDA2; HED1; ODT1; XHED; ECTD1; XLHED; ED1-A1; ED1-A2; EDA-A1; EDA-A2; STHAGX1; ectodysplasin-A; oligodontia 1; X-linked anhidroitic ectodermal dysplasia protein;
- Gene ID
- 1896
- UniProt ID
- Q92838
Downloads
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Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-269MZ | Mouse Anti-EDA Recombinant Antibody (TAB-269MZ) | ELISA | Mouse IgG |
| TAB-269MZ-S(P) | Mouse Anti-EDA Recombinant Antibody; scFv Fragment (TAB-269MZ-S(P)) | ELISA | Mouse scFv |
| TAB-269MZ-F(E) | Mouse Anti-EDA Recombinant Antibody; Fab Fragment (TAB-269MZ-F(E)) | ELISA | Mouse Fab |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0160CT | Recombinant Mouse anti-Human EDA Monoclonal antibody (NN0365-4U3) | WB | |
| FAMAB-0123CQ | Mouse Anti-EDA Recombinant Antibody (clone EctoD1) | ELISA, WB | Mouse IgG1 |
| FAMAB-0124CQ | Mouse Anti-EDA Recombinant Antibody (clone EctoD2) | ELISA, WB, Block | Mouse IgG1 |
| FAMAB-0125CQ | Mouse Anti-EDA Recombinant Antibody (clone EctoD3) | ELISA, WB, Block | Mouse IgG1 |
| VS-0723-WK150 | Human Anti-EDA Recombinant Antibody (VS-0723-WK150) | FC | Chimeric (rabbit/human) IgG1 |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0123CQ-F(E) | Mouse Anti-EDA Recombinant Antibody (clone EctoD1); Fab Fragment | ELISA, WB | Mouse Fab |
| FAMAB-0124CQ-F(E) | Mouse Anti-EDA Recombinant Antibody (clone EctoD2); Fab Fragment | ELISA, WB, Block | Mouse Fab |
| FAMAB-0125CQ-F(E) | Mouse Anti-EDA Recombinant Antibody (clone EctoD3); Fab Fragment | ELISA, WB, Block | Mouse Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0123CQ-S(P) | Mouse Anti-EDA Recombinant Antibody (clone EctoD1); scFv Fragment | ELISA, WB | Mouse scFv |
| FAMAB-0124CQ-S(P) | Mouse Anti-EDA Recombinant Antibody (clone EctoD2); scFv Fragment | ELISA, WB, Block | Mouse scFv |
| FAMAB-0125CQ-S(P) | Mouse Anti-EDA Recombinant Antibody (clone EctoD3); scFv Fragment | ELISA, WB, Block | Mouse scFv |
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