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CD40
Anti-Human CD40 Recombinant Antibody (Selicrelumab)

Anti-Human CD40 Recombinant Antibody (Selicrelumab) (CAT#: TAB-470CQ)

Recombinant monoclonal antibody to CD40. Selicrelumab is a human monoclonal antibody that can be potentially used in the treatment of Solid tumors.

See more Engineered Antibody products for CD40

Published Data
Tested Data
Gene Expression
Datasheet
MSDS
COA

Figure 1 Assessment of TME by histopathologic and immunohistochemistry of the surgical resection specimen.

Figure 1 Assessment of TME by histopathologic and immunohistochemistry of the surgical resection specimen.

Representative images of Mason's trichrome staining from (A) treatment naïve cohort of UPenn patients or (B) patients treated with selicrelumab (Arm I). Red lines indicate the border of tumor regions. (C) Quantification of percent fibrosis in the TME for a set of untreated control PDAC resection samples and samples from Arm I and Arm II, as indicated.

Byrne, K. T., Betts, C. B., Mick, R., Sivagnanam, S., Bajor, D. L., Laheru, D. A., ... & Vonderheide, R. H. (2021). Neoadjuvant selicrelumab, an agonist CD40 antibody, induces changes in the tumor microenvironment in patients with resectable pancreatic cancer. Clinical Cancer Research, 27(16), 4574-4586.

SDS-PAGE

Figure 1 Anti-Human CD40 Recombinant Antibody (Selicrelumab) (TAB-470CQ) in SDS-PAGE

Figure 1 Anti-Human CD40 Recombinant Antibody (Selicrelumab) (TAB-470CQ) in SDS-PAGE

SDS-PAGE analysis of TAB-470CQ in non-reduced (Lane 1) and reduced (Lane 2) conditions. Gel stained for 30 minutes with Coomassie Blue. As a result, different β-mercaptoethanol-reduced proteins (Heavy chain and Light chain) migrate as about 50 kDa and 25 kDa, respectively.

The purity of TAB-470CQ was greater than 95% as determined by SDS-PAGE.

SEC-HPLC

Figure 2 Anti-Human CD40 Recombinant Antibody (Selicrelumab) (TAB-470CQ) in HPLC

Figure 2 Anti-Human CD40 Recombinant Antibody (Selicrelumab) (TAB-470CQ) in HPLC

HPLC analysis of TAB-470CQ shows the purity is>95%.

Figure 3 Anti-Human CD40 Recombinant Antibody (Selicrelumab) (TAB-470CQ) in WB

Figure 3 Anti-Human CD40 Recombinant Antibody (Selicrelumab) (TAB-470CQ) in WB

Western blot analysis of TAB-470CQ was performed by loading human CD40.
TAB-470CQ incubation concentration: 2ng/μL.
The secondary antibody: HRP-Anti-Human IgG (H+L)
Lane1: Reducing antigen (0.1μg)
Lane2: Reducing antigen (0.3μg)
Lane3: Reducing antigen (0.6μg)

ELISA

Figure 4 Anti-Human CD40 Recombinant Antibody (Selicrelumab) (TAB-470CQ) in ELISA

Figure 4 Anti-Human CD40 Recombinant Antibody (Selicrelumab) (TAB-470CQ) in ELISA

ELISA analysis of TAB-470CQ was performed by coating with human CD40.
The secondary antibody: HRP-Anti-Human IgG (H+L)

Normal Tissue

Figure 1 Lymph node
(Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72868/156401_A_8_8.jpg

Figure 2 Tonsil
(Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31567/156626_A_6_8.jpg

RNA Expression

Figure 3 RNA cell line category: Cell line enhanced (CAPAN-2, Daudi, EFO-21)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000101017-CD40

Datasheet

MSDS

Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number

Specifications

Immunogen
The details of the immunogen for this antibody are not available.

Host Species
Human

Derivation
Human

Type
IgG2, κ

Specificity
Human CD40

Species Reactivity
Human

Applications
ELISA, IHC, FC, IP, IF, FuncS

Conjugate
Unconjugated

CAS
1622140-49-1

Generic Name
Selicrelumab

UNII
0O39RGI33V

Related Disease
Solid tumors

Product Property

Purity
> 95% as determined by SDS-PAGE

Storage
Store at -20°C for long-term storage. Avoid freeze/thaw cycles.

Applications

Application Notes
The CD40 antibody has been reported in applications of PK.
Pharmacokinetic: Lucatumumab serum levels were collected before dosing, at the end of the infusion, 2 h after the end of the infusion and 24, 48, 96 and 168 h after the start of the first and fourth infusions. Additional time points beyond 168 h were collected after the fourth infusion at 336, 504, 672 and 840 h and every other week thereafter as well as before and after the second and third infusions.

Target

Alternative Names
p50; Bp50; CDW40; TNFRSF5

Gene ID
958

UniProt ID
P25942

Related Resources

Related Diseases

Asthma

Systemic Lupus Erythematosus

Primary Immunodeficiency

Allograft Rejection

Autoimmune Thyroid Disease

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Selicrelumab"

Afuco™ Anti-CD40 ADCC Recombinant Antibody (Selicrelumab), ADCC Enhanced
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to CD40. Selicrelumab is a human monoclonal antibody that can be potentially used in the treatment of Solid tumors.

See other products for "CD40"

Human Antibody

CAT	Product Name	Application	Type
TAB-759	Anti-CD40 Recombinant Antibody (Lucatumumab)	ELISA, FC, IP, FuncS, IF, Neut, IHC	IgG1 - kappa
TAB-195LC-S(P)	Human Anti-CD40 Recombinant Antibody; scFv Fragment (TAB-195LC-S(P))	ELISA	Human scFv
TAB-196LC-S(P)	Human Anti-CD40 Recombinant Antibody; scFv Fragment (TAB-196LC-S(P))	ELISA	Human scFv
TAB-197LC-S(P)	Human Anti-CD40 Recombinant Antibody; scFv Fragment (TAB-197LC-S(P))	ELISA	Human scFv
TAB-198LC-S(P)	Human Anti-CD40 Recombinant Antibody; scFv Fragment (TAB-198LC-S(P))	ELISA	Human scFv

Humanized Antibody

CAT	Product Name	Application	Type
TAB-152	Anti-Human CD40 Recombinant Antibody (Dacetuzumab)	IF, IP, Neut, FuncS, ELISA, FC, ICC	IgG1
TAB-126CL	Human Anti-CD40 Recombinant Antibody (TAB-126CL)	Block, Cyt, FuncS, Inhib	Human IgG
TAB-200LC-F(E)	Human Anti-CD40 Recombinant Antibody; Fab Fragment (TAB-200LC-F(E))	ELISA	Human Fab
TAB-204LC-F(E)	Human Anti-CD40 Recombinant Antibody; Fab Fragment (TAB-204LC-F(E))	SPR, ELISA	Human Fab
TAB-205LC-F(E)	Human Anti-CD40 Recombinant Antibody; Fab Fragment (TAB-205LC-F(E))	SPR, ELISA	Human Fab

Immunotoxin

CAT	Product Name	Application	Type
AGTO-G079E	Anti-CD40 immunotoxin G28-5 (scFv)-PE	Cytotoxicity assay, Function study

Mouse Antibody

CAT	Product Name	Application	Type
TAB-207LC	Mouse Anti-CD40 Recombinant Antibody (TAB-207LC)	ELISA	Mouse IgG, κ
TAB-208LC	Mouse Anti-CD40 Recombinant Antibody (TAB-208LC)	ELISA	Mouse IgG, κ
TAB-209LC	Mouse Anti-CD40 Recombinant Antibody (TAB-209LC)	ELISA	Mouse IgG, κ
TAB-208LC-F(E)	Mouse Anti-CD40 Recombinant Antibody; Fab Fragment (TAB-208LC-F(E))	ELISA	Mouse Fab
TAB-209LC-F(E)	Mouse Anti-CD40 Recombinant Antibody; Fab Fragment (TAB-209LC-F(E))	ELISA	Mouse Fab

Chimeric Antibody

CAT	Product Name	Application	Type
TAB-192LC-S(P)	Mouse Anti-CD40 Recombinant Antibody; scFv Fragment (TAB-192LC-S(P))	ELISA	Mouse scFv
TAB-193LC-S(P)	Mouse Anti-CD40 Recombinant Antibody; scFv Fragment (TAB-193LC-S(P))	ELISA	Mouse scFv
TAB-202LC-S(P)	Anti-CD40 Recombinant Antibody; scFv Fragment (TAB-202LC-S(P))	FC, ELISA	scFv
TAB-192LC-F(E)	Human Anti-CD40 Recombinant Antibody; Fab Fragment (TAB-192LC-F(E))	ELISA	Chimeric (mouse/human) Fab
TAB-193LC-F(E)	Human Anti-CD40 Recombinant Antibody; Fab Fragment (TAB-193LC-F(E))	ELISA	Chimeric (mouse/human) Fab

Blocking Antibody

CAT	Product Name	Application	Type
NEUT-362CQ	Human Anti-CD40 Recombinant Antibody (clone 5D12)	Block, ELISA, FC, SPR, IP, IHC	Human IgG4, κ
NEUT-363CQ	Mouse Anti-CD40 Recombinant Antibody (clone 5C3)	FC, Block, Activ	Mouse IgG1, κ
NEUT-365CQ	Hamster Anti-CD40 Recombinant Antibody (clone HM40-3)	FC, Block, Costim, IHC	Hamster IgM
NEUT-366CQ	Rat Anti-CD40 Recombinant Antibody (clone MAB0819)	Block, Activ	Rat IgG2

Neutralizing Antibody

CAT	Product Name	Application	Type
NEUT-364CQ	Mouse Anti-CD40 Recombinant Antibody (clone CBL829)	WB, Neut	Mouse IgG2b, κ
NEUT-367CQ	Mouse Anti-CD40 Recombinant Antibody (clone CBL013)	WB, IHC, Neut	Mouse IgG2

Rabbit Monoclonal Antibody

CAT	Product Name	Application	Type
MOR-4059	Hi-Affi™ Rabbit Anti-CD40 Recombinant Antibody (clone SI126DS)	ELISA	Rabbit IgG

Agonistic Antibody

CAT	Product Name	Application	Type
MOB-105LC	Human Anti-CD40 Recombinant Antibody (MOB-105LC)	FC, FuncS	Human IgG1, κ
MOB-106LC	Human Anti-CD40 Recombinant Antibody (MOB-106LC)	FC, FuncS, ELISA	Human IgG2, κ
MOB-107LC	Human Anti-CD40 Recombinant Antibody (MOB-107LC)	FC, FuncS, ELISA	Human IgG2, κ

Recombinant Antibody

CAT	Product Name	Application	Type
HPAB-0164-YC	Human Anti-CD40 Recombinant Antibody (HPAB-0164-YC)	FC, Agonist	Human IgG
HPAB-0165-YC	Human Anti-CD40 Recombinant Antibody (HPAB-0165-YC)	FC	Human IgG
HPAB-0166-YC	Human Anti-CD40 Recombinant Antibody (clone S2C6)	FC, FuncS	Human IgG
HPAB-0167-YC	Human Anti-CD40 Recombinant Antibody (HPAB-0167-YC)	ELISA, FC, Neut, Agonist	Human IgG2, κ
HPAB-0168-YC	Human Anti-CD40 Recombinant Antibody (HPAB-0168-YC)	ELISA, FC, Neut, FuncS	Human IgG1, κ

Neuroscience Antibody

CAT	Product Name	Application	Type
NS-021CN	Human Anti-CD40 Recombinant Antibody (NS-021CN)	ELISA, IF, Block, FuncS	Human IgG
NS-021CN-F(E)	Human Anti-CD40 Recombinant Antibody; Fab Fragment (NS-021CN-F(E))	ELISA	Human Fab
NS-021CN-S(P)	Human Anti-CD40 Recombinant Antibody; scFv Fragment (NS-021CN-S(P))	ELISA	Human scFv

scFv Fragment Antibody

CAT	Product Name	Application	Type
HPAB-0009-WJ-S(P)	Human Anti-CD40 Recombinant Antibody; scFv Fragment (HPAB-0009-WJ-S(P))	ELISA	Human scFv
PSBC-514	Human Anti-CD40 Recombinant Antibody (clone Chi Lob 7/4); scFv Fragment	ELISA, FC, WB, Agonist	Mouse scFv
HPAB-M0030-YC-S(P)	Human Anti-CD40 Recombinant Antibody; scFv Fragment (HPAB-M0030-YC-S(P))	ELISA, FuncS	Human scFv
HPAB-M0031-YC-S(P)	Human Anti-CD40 Recombinant Antibody; scFv Fragment (HPAB-M0031-YC-S(P))	ELISA, FuncS	Human scFv
HPAB-1834-FY-F(E)	Human Anti-CD40 Recombinant Antibody (clone 21.4.1); scFv Fragment	Agonist, Activ	Human scFv

Fab Fragment Antibody

CAT	Product Name	Application	Type
HPAB-1110LY-F(E)	Mouse Anti-CD40 Recombinant Antibody (clone CBL020); Fab Fragment	ELISA	Mouse Fab
HPAB-1662LY-F(E)	Mouse Anti-CD40 Recombinant Antibody; Fab Fragment (HPAB-1662LY-F(E))	ELISA, RIA	Mouse Fab
HPAB-1663LY-F(E)	Mouse Anti-CD40 Recombinant Antibody; Fab Fragment (HPAB-1663LY-F(E))	ELISA, RIA	Mouse Fab
HPAB-1664LY-F(E)	Mouse Anti-CD40 Recombinant Antibody; Fab Fragment (HPAB-1664LY-F(E))	ELISA, RIA	Mouse Fab
PFBC-514	Human Anti-CD40 Recombinant Antibody (clone Chi Lob 7/4); Fab Fragment	ELISA, FC, WB, Agonist	Human Fab

ADCC Enhanced Antibody

CAT	Product Name	Application	Type
AFC-TAB-152	Afuco™ Anti-CD40 ADCC Recombinant Antibody (Dacetuzumab), ADCC Enhanced	IF, IP, Neut, FuncS, ELISA, FC	ADCC enhanced antibody
AFC-TAB-262	Afuco™ Anti-CD40 ADCC Recombinant Antibody (Teneliximab), ADCC Enhanced	IP, IF, FuncS, FC, Neut, ELISA	ADCC enhanced antibody
AFC-TAB-759	Afuco™ Anti-CD40 ADCC Recombinant Antibody (Lucatumumab), ADCC Enhanced	ELISA, FC, IP, FuncS, IF, Neut	ADCC enhanced antibody
AFC-TAB-470CQ	Afuco™ Anti-CD40 ADCC Recombinant Antibody (Selicrelumab), ADCC Enhanced	ELISA, IHC, FC, IP, IF, FuncS	ADCC enhanced antibody
AFC-TAB-006ML	Afuco™ Anti-CD40 ADCC Recombinant Antibody (Bleselumab), ADCC Enhanced	ELISA, IHC, FC, IP, IF, Inhib	ADCC enhanced antibody

Single-domain Antibody

CAT	Product Name	Application	Type
HPAB-1218WJ	Recombinant Llama Anti-CD40 Single Domain Antibody (CD40-1)	ELISA	Llama VHH
HPAB-1219WJ	Recombinant Llama Anti-CD40 Single Domain Antibody (CD40-2)	ELISA	Llama VHH
HPAB-1220WJ	Recombinant Llama Anti-CD40 Single Domain Antibody (CD40-3)	ELISA	Llama VHH

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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