Anti-CEACAM1 (T84.66) scFv-dextran T-40-MMC ADC (CAT#: ADC-090LCT)

This ADC product is composed of an anti-CEACAM1 antibody (clone T84.66) conjuagated via a dextran T-40 linker to mitomycin (MMC) (T84.66 scFv-dextran T-40-MMC). It has demonstrated a response in colorectal cancer treatment.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Normal Tissue
RNA Expression

Specifications

  • Antibody Overview
  • Anti-CEA scFv T84.66
  • Clone
  • anti-CEA scFv T84.66
  • Linker
  • dextran T-40
  • Drug
  • mitomycin (MMC)

Target

  • Introduction
  • This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined.
  • Alternative Names
  • BGP; BGP1; BGPI

Downloads

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See other products for "CEACAM1"

Mouse Antibody

CAT Product Name Application Type
TAB-014-F(E) Anti-Human CEA Recombinant Antibody Fab Fragment (Arcitumomab) FuncS, IF, Neut, ELISA, FC, IP, ICC Fab' - G1

Humanized Antibody

CAT Product Name Application Type
TAB-156CL Human Anti-CEACAM1 Recombinant Antibody (TAB-156CL) ELISA Human IgG

Chimeric Antibody

CAT Product Name Application Type
TAB-443LC Human Anti-CEACAM1 Recombinant Antibody (TAB-443LC) Block, Cyt, ELISA, FC, FuncS Chimeric (Mouse/Human) IgG1, κ
TAB-443LC-S(P) Mouse Anti-CEACAM1 Recombinant Antibody; scFv Fragment (TAB-443LC-S(P)) FC, SPR, IHC, ELISA Mouse scFv
TAB-443LC-F(E) Human Anti-CEACAM1 Recombinant Antibody; Fab Fragment (TAB-443LC-F(E)) FC, SPR, IHC, ELISA Chimeric (Mouse/Human) Fab

Blocking Antibody

CAT Product Name Application Type
NEUT-453CQ Mouse Anti-Ceacam1 Recombinant Antibody (clone MAb-CC1) FC, WB, IP, IHC, ELISA, Block Mouse IgG1, κ

Neutralizing Antibody

CAT Product Name Application Type
NEUT-454CQ Mouse Anti-Ceacam1 Recombinant Antibody (clone CC1) WB, Neut, FC, FuncS, IHC, IHC-Fr, IHC-P, IP Mouse IgG1

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0648 Hi-Affi™ Rabbit Anti-CEACAM1 Recombinant Antibody (clone DS648AB) IHC-P, WB Rabbit IgG

Epitope-Specific Antibody

CAT Product Name Application Type
EPAF-0572CQ Rat Anti-CEACAM1 Recombinant Antibody (clone YTH71.3) ELISA Rat IgG2a

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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