TRX4 (CAT#: Gly-002CL)
TRX4 is a monoclonal antibody that binds to a receptor found on all T cells called CD3, which is involved in normal T cell signaling. TRX4 is believed to inhibit the function of autoreactive T cells, which are important in propagating autoimmune diseases, while inducing regulatory T cell pathways that promote immunological tolerance and inhibit autoreactive disease activity. Tolerx is developing TRX4 to treat patients with type 1 diabetes, psoriasis and other autoimmune diseases such as rheumatoid arthritis.
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Specifications
- Type
- Small Molecule
- Mechanism of action
- TRX4 is a monoclonal antibody that binds to a receptor found on all T cells called CD3, which is involved in normal T cell signaling. TRX4 is believed to inhibit the function of autoreactive T cells, which are important in propagating autoimmune diseases, while inducing regulatory T cell pathways that promote immunological tolerance and inhibit autoreactive disease activity.
References
- Synonyms
- Otelixizumab
Downloads
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Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0417CL | Chimeric Anti-Human CD3 Recombinant Antibody | ELISA, FC, FuncS | Chimeric (mouse/human) |
| TAB-071LC-S(P) | Anti-Human CD3 Recombinant Antibody scFv Fragment | ELISA | Chimeric antibody (mouse/human) |
| TAB-072LC-S(P) | Chimeric Anti-Human CD3 Recombinant Antibody scFv Fragment | ELISA | Chimeric antibody (mouse/human) |
| TAB-071LC-F(E) | Anti-Human CD3 Recombinant Antibody Fab Fragment | ELISA | Chimeric antibody (mouse/human) |
| TAB-072LC-F(E) | Chimeric Anti-Human CD3 Recombinant Antibody Fab Fragment | ELISA | Chimeric antibody (mouse/human) |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0418CL | Humanized Anti-Human CD3 Recombinant Antibody | ELISA, FC, FuncS | Humanized Antibody |
| TAB-079LC | Human Anti-CD3 Recombinant Antibody (TAB-079LC) | ELISA, FC, FuncS | Human IgG1, κ |
| TAB-080LC | Human Anti-CD3 Recombinant Antibody (TAB-080LC) | ELISA, FC, FuncS | Human IgG1, κ |
| TAB-081LC | Human Anti-CD3 Recombinant Antibody (TAB-081LC) | ELISA, FC | Human IgG1, κ |
| TAB-083LC | Human Anti-CD3 Recombinant Antibody (TAB-083LC) | ELISA, FC | Human IgG1, κ |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0365CL-S(P) | Anti-Mouse CD3 Recombinant Antibody scFv Fragment (Dow2) | IP, IB, FuncS | |
| TAB-0416CL-S(P) | Anti-Human CD3 Recombinant Antibody scFv Fragment (OKT3) | IB, ELISA, FC, FuncS | |
| TAB-0422CL-F(E) | Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (TAB-0422CL-F(E)) | ELISA | Mouse Fab |
| TAB-540CT | Mouse Anti-CD3 Recombinant Antibody (TAB-540CT) | ELISA, FC | Mouse IgG1 |
| TAB-540CT-F(E) | Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (TAB-540CT-F(E)) | ELISA, FC | Mouse Fab |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-339CQ | Mouse Anti-CD3 Recombinant Antibody (clone SPV-T3b) | FC, Block, IHC-Fr, IF, WB | Mouse IgG2a |
| NEUT-340CQ | Mouse Anti-CD3 Recombinant Antibody (clone UCHT1) | FC, IHC-Fr, IHC-P, ICC, IP, WB, Activ, Block | Mouse IgG1, κ |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0043CQ | Mouse Anti-CD3 Recombinant Antibody (clone 898H2-6-15) | ELISA, FuncS | Mouse IgG2a, κ |
| FAMAB-0044CQ | Mouse Anti-CD3 Recombinant Antibody (clone FN18) | ELISA, WB, FC, FuncS | Mouse IgG, κ |
| HPAB-0672LY | Mouse Anti-CD3 Recombinant Antibody (HPAB-0672LY) | ELISA, FC | Mouse IgG1 |
| HPAB-0673LY | Mouse Anti-CD3 Recombinant Antibody (HPAB-0673LY) | ELISA, FC | Mouse IgG1 |
| HPAB-0674LY | Mouse Anti-CD3 Recombinant Antibody (HPAB-0674LY) | ELISA, FC | Mouse IgG1 |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1793LY-S(P) | Human Anti-CD3 Recombinant Antibody; scFv Fragment (HPAB-1793LY-S(P)) | ELISA | Human scfv |
| HPAB-1101-CN-S(P) | Human Anti-CD3 Recombinant Antibody; scFv Fragment (HPAB-1101-CN-S(P)) | ELISA, FC | Humanized scFv |
| HPAB-0441-YJ-S(P) | Mouse Anti-CD3 Recombinant Antibody (clone m3E3); scFv Fragment | ELISA, FC | Mouse scFv |
| HPAB-0442-YJ-S(P) | Mouse Anti-CD3 Recombinant Antibody (clone hc3E3); scFv Fragment | ELISA, FC | Mouse scFv |
| HPAB-1181WJ-S(P) | Human Anti-CD3 Recombinant Antibody (clone CBLC-007); scFv Fragment | ELISA | Humanized scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0667LY-F(E) | Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (HPAB-0667LY-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-0668LY-F(E) | Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (HPAB-0668LY-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-0669LY-F(E) | Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (HPAB-0669LY-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-0670LY-F(E) | Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (HPAB-0670LY-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-0671LY-F(E) | Mouse Anti-CD3 Recombinant Antibody; Fab Fragment (HPAB-0671LY-F(E)) | ELISA, FC | Mouse Fab |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0378-YC | Recombinant Llama Anti-CD3 Single Domain Antibody (A30228) | ELISA, FC | Llama VHH |
| HPAB-M0379-YC | Recombinant Llama Anti-CD3 Single Domain Antibody (A30311) | ELISA, FC | Llama VHH |
| HPAB-1029WJ | Recombinant Camelid Anti-CD3 Single Domain Antibody | ELISA | Camelid VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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