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TX14A-Sap immunotoxin (AGTO-L072S)

This immunotoxin was achieved by conjugating/fusing the TX14A to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to cells expressed saposin C and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of prostate, lung, breast, and colon cancer.      

Specifications
Host
Human
Species Reactivity
Human
Molecule Class
TX14A-Sap
Toxin Description
Saporin is a so-called ribosome inactivating protein (RIP), due to its N-glycosidase activity, from the seeds of Saponaria officinalis (common name: soapwort).Saporin depurinate the ribosomal RNA in a specific position; rendering the large subunit of ribosomes unable to bind the elongation factors. The consequent arrest of protein synthesis is responsible for the cytotoxicity.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
Prostate, lung, breast, and colon cancer
Target
Alternative Names
Prostate cancer; lungcancer; breastcancer; colon cancer; A1 activator; Cerebroside sulfate activator; Co-beta-glucosidase; Component C

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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