Products

Tenecteplase (TP-049CL)

Tissue plasminogen activator (tPA). Tenecteplase is a 527 amino acid glycoprotein developed by introducing the following modifications to the complementary DNA (cDNA) for natural human tPA: a substitution of threonine 103 with asparagine, and a substitution of asparagine 117 with glutamine, both within the kringle 1 domain, and a tetra-alanine substitution at amino acids 296-299 in the protease domain.      

Specifications
Classify
Protein therapeutics augmenting an existing pathway: Haemostasis and thrombosis
Therapeutic
Tenecteplase
Trade Name
Tnkase
Function
TPA with greater specificity for plasminogen conversion; has amino-acid substitutions of Thr103 to Asp, Asp117 to Gln, and Ala for amino-acids 296–299
Examples of Clinical Use
Acute myocardial infarction
References
Synonyms
t- PA, t-plasminogen activator, Tissue-type plasminogen activator precursor, tPA
UniProt
P00750
Genbank
L00153

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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