Tenecteplase (CAT#: TP-049CL)
Tissue plasminogen activator (tPA). Tenecteplase is a 527 amino acid glycoprotein developed by introducing the following modifications to the complementary DNA (cDNA) for natural human tPA: a substitution of threonine 103 with asparagine, and a substitution of asparagine 117 with glutamine, both within the kringle 1 domain, and a tetra-alanine substitution at amino acids 296-299 in the protease domain.
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to actin filaments.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3412/if_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to actin filaments.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3412/if_selected.jpg
Figure 2 IHC staining of human duodenum
(Immunohistochemical staining of human duodenum shows strong positivity in plasma.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3412/ihc_selected.jpg
(Immunohistochemical staining of human duodenum shows strong positivity in plasma.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3412/ihc_selected.jpg
Figure 3 Cerebral cortex
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3412/11857_B_8_5.jpg
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3412/11857_B_8_5.jpg
Figure 4 Liver
(Hepatocytes
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3412/11857_A_9_4.jpg
(Hepatocytes
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3412/11857_A_9_4.jpg
Figure 5 Kidney
(Cells in tubules
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3412/11857_A_9_5.jpg
(Cells in tubules
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3412/11857_A_9_5.jpg
Figure 6 Lymph node
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3412/11857_A_9_8.jpg
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3412/11857_A_9_8.jpg
Figure 7 RNA cell line category: Cell line enhanced (CAPAN-2, HMC-1, hTERT-RPE1, LHCN-M2, U-2197, WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000104368-PLAT/subcellular
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000104368-PLAT/subcellular
Specifications
- Classify
- Protein therapeutics augmenting an existing pathway: Haemostasis and thrombosis
- Therapeutic
- Tenecteplase
- Trade Name
- Tnkase
- Function
- TPA with greater specificity for plasminogen conversion; has amino-acid substitutions of Thr103 to Asp, Asp117 to Gln, and Ala for amino-acids 296–299
- Examples of clinical use
- Acute myocardial infarction
References
- Synonyms
- t- PA, t-plasminogen activator, Tissue-type plasminogen activator precursor, tPA
- UniProt
- P00750
- Genbank
- L00153
Downloads
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See other products for "PLAT"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2092CT | Recombinant Mouse anti-Human PLAT Monoclonal antibody (3B264) | IHC-FoFr, WB | |
| MRO-1500-CN | Recombinant Rabbit Anti-PLAT Monoclonal Antibody (JF0958) | WB, IHC | Rabbit IgG |
| VS3-QX885 | Mouse Anti-PLAT Recombinant Antibody (clone AH54-10) | ELISA, WB, ICC, IHC | Mouse IgG1 |
| VS3-QX886 | Mouse Anti-PLAT Recombinant Antibody (clone AH81-00) | ELISA, WB, ICC, IHC | Mouse IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2735 | Hi-Affi™ Recombinant Rabbit Anti-PLAT Monoclonal Antibody (DS2735AB) | ELISA, WB | IgG |
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