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Anti-IL-13-Rα2 (clone hu08)-mc ADC (CAT#: ADC-033CL)

This ADC product is composed of an anti-IL-13-Rα2 antibody (clone hu08) conjugated via mc linker to drug payload (hu08-mc-3906). It has demonstrated a response in IL-13-Ra2 expressing cancer treatment.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Figure 1 IF staining of human cell line BJ
Figure 1 IF staining of human cell line BJ
(Immunofluorescent staining of human cell line BJ shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/45831/1866_G1_31_selected.jpg
Figure 2 IF staining of human cell line U-2 OS
Figure 2 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to cell junctions.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/67363/1754_D2_3_cr57f3cf6655f7f_selected.jpg
RNA Expression
Figure 3 RNA cell line category: Group enriched (PC-3, U-2197, U-251 MG, U-87 MG)
Figure 3 RNA cell line category: Group enriched (PC-3, U-2197, U-251 MG, U-87 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000123496-IL13RA2

Specifications

  • Antibody Overview
  • Humanized Anti-IL-13-Ra2 lgG1 Antibody hu08
  • Clone
  • hu08
  • Linker
  • Mc (maleimidocaproyl)
  • Linker Class/Description
  • Class: Noncleavable linkers
    Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.

Target

  • Introduction
  • The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. [provided by RefSeq, Jul 2008]
  • Alternative Names
  • IL13RA2; interleukin 13 receptor, alpha 2; CT19; IL-13R; IL13BP; CD213A2; interleukin-13 receptor subunit alpha-2; IL-13RA2; IL-13R-alpha-2; IL-13R subunit alpha-2; cancer/testis antigen 19; IL-13 receptor subunit alpha-2; interleukin 13 binding protein; interleukin-13-binding protein; interleukin 13 receptor alpha 2 chain;

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Recombinant Antibody

CAT Product Name Application Type
MOB-555 Recombinant Anti-human IL13RA2 Antibody WB, Neut, FuncS IgG
MHH-555 Recombinant Human Anti-human IL13RA2 Antibody ELISA, IP, FuncS IgG
MOB-0783CT Recombinant Mouse anti-Human IL13RA2 Monoclonal antibody (EML442) FC, ICC/IF, IHC-Fr, IHC-P, IP, WB
HPAB-0999WJ Mouse Anti-IL13RA2 Recombinant Antibody (clone FMMU-IL_13Ra 2-7) ELISA, FC, IHC Mouse IgG
HPAB-J0128-YC Mouse Anti-IL13RA2 Recombinant Antibody (clone FMMU-IL-13R alpha 2-7) ELISA, FC Mouse IgG

Fab Fragment Antibody

CAT Product Name Application Type
MOB-555-F(E) Recombinant Anti-human IL13RA2 Antibody Fab Fragment IP, IF, FuncS Fab
MHH-555-F(E) Recombinant Human Anti-human IL13RA2 Antibody Fab Fragment IP, IF, FuncS Fab
HPAB-0999WJ-F(E) Mouse Anti-IL13RA2 Recombinant Antibody (clone FMMU-IL_13Ra 2-7); Fab Fragment ELISA, FC, IHC Mouse Fab
HPAB-J0128-YC-F(E) Mouse Anti-IL13RA2 Recombinant Antibody (clone FMMU-IL-13R alpha 2-7); Fab Fragment ELISA, FC Mouse Fab

scFv Fragment Antibody

CAT Product Name Application Type
MOB-555-S(P) Recombinant Anti-human IL13RA2 Antibody scFv Fragment ELISA, WB, FuncS scFv
MHH-555-S(P) Recombinant Human Anti-human IL13RA2 Antibody scFv Fragment IF, FC, Biosensors, FuncS scFv
HPAB-0999WJ-S(P) Mouse Anti-IL13RA2 Recombinant Antibody (clone FMMU-IL_13Ra 2-7); scFv Fragment ELISA, FC, IHC Mouse scFv
HPAB-J0128-YC-S(P) Mouse Anti-IL13RA2 Recombinant Antibody (clone FMMU-IL-13R alpha 2-7); scFv Fragment ELISA, FC Mouse scFv

Immunotoxin

CAT Product Name Application Type
AGTO-G040E IL-13-PE immunotoxin Cytotoxicity assay, Function study
AGTO-G040D IL-13-DT immunotoxin Cytotoxicity assay, Function study

Humanized Antibody

CAT Product Name Application Type
TAB-0158CL-F(E) Human Anti-IL13RA2 Recombinant Antibody; Fab Fragment (TAB-0158CL-F(E)) ELISA, Internalization, BI, FuncS Humanized Fab
TAB-0159CL-F(E) Human Anti-IL13RA2 Recombinant Antibody; Fab Fragment (TAB-0159CL-F(E)) ELISA, Internalization, BI, FuncS Humanized Fab
TAB-0160CL-F(E) Human Anti-IL13RA2 Recombinant Antibody; Fab Fragment (TAB-0160CL-F(E)) ELISA, Internalization, BI, FuncS Humanized Fab
TAB-0161CL-F(E) Human Anti-IL13RA2 Recombinant Antibody; Fab Fragment (TAB-0161CL-F(E)) ELISA, Internalization, BI, FuncS Humanized Fab
TAB-0162CL-F(E) Human Anti-IL13RA2 Recombinant Antibody; Fab Fragment (TAB-0162CL-F(E)) ELISA, Internalization, BI, FuncS Humanized Fab

Mouse Antibody

CAT Product Name Application Type
TAB-024ZJ Mouse Anti-IL13RA2 Recombinant Antibody (TAB-024ZJ) ELISA, WB, IP, IF, IHC, FC Mouse IgG2b, κ
TAB-025ZJ Mouse Anti-IL13RA2 Recombinant Antibody (TAB-025ZJ) ELISA, WB, IP, IF, IHC, FC Mouse IgM, κ
TAB-026ZJ Mouse Anti-IL13RA2 Recombinant Antibody (TAB-026ZJ) ELISA, WB, IP, IF, IHC, FC Mouse IgG1, κ
TAB-024ZJ-S(P) Mouse Anti-IL13RA2 Recombinant Antibody; scFv Fragment (TAB-024ZJ-S(P)) ELISA, WB, IP, IF, IHC, FC Mouse scFv
TAB-025ZJ-S(P) Mouse Anti-IL13RA2 Recombinant Antibody; scFv Fragment (TAB-025ZJ-S(P)) ELISA, WB, IP, IF, IHC, FC Mouse scFv

Human Antibody

CAT Product Name Application Type
TAB-383CQ Human Anti-IL13RA2 Recombinant Antibody (TAB-383CQ) ELISA Human IgG
TAB-383CQ-S(P) Human Anti-IL13RA2 Recombinant Antibody; scFv Fragment (TAB-383CQ-S(P)) ELISA Human scFv
TAB-383CQ-F(E) Human Anti-IL13RA2 Recombinant Antibody; Fab Fragment (TAB-383CQ-F(E)) ELISA Human Fab

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0279MZ Chicken Anti-Interleukin-13 Receptor α2 Polyclonal IgY WB Chicken antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-1190CQ Mouse Anti-IL13RA2 Recombinant Antibody (VMC188) FC, ELISA, IHC, Block Mouse IgG1, κ

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-4241 Rabbit Anti-IL13RA2 Recombinant Antibody (clone SI320DS) ELISA Rabbit IgG

MHC Tetramer for Cancer

CAT Product Name Application Type
MHC-CN0905 PE-A*24:02/Human IL13RA2 (VYYNWQYLL) MHC Tetramer FCM, IHC
MHC-CN0906 APC-A*24:02/Human IL13RA2 (VYYNWQYLL) MHC Tetramer FCM, IHC
MHC-CN0907 FITC-A*24:02/Human IL13RA2 (VYYNWQYLL) MHC Tetramer FCM, IHC
MHC-CN0908 A*24:02/Human IL13RA2 (VYYNWQYLL) MHC Tetramer FCM, IHC
MHC-YF499 A*24:02/Human IL13R (VYYNWQYLL) MHC Pentamer FCM

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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