Z-domain of protein A scaffold protein anti-Human apolipoprotein A-1 variant (CAT#: SZA-L228)

This human apolipoprotein A-1 variant specific binding protein (Z-domain of protein A) was investigated by an α-helix shuffling strategy. The primary scaffold protein was from a naive combinatorial library of the three-helix bundle Z domain derived from staphylococcal protein A. A hierarchical library was constructed through selective re-randomization of six amino acid positions in one of the two α-helices of the domain, making up the Taq DNA polymerase binding surface. After selections using monovalent phage display technology, second generation variants were identified having affinities for human apolipoprotein A-1 variant as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.


Specific Inquiry
  • Size:
  • Conjugation:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Scaffold Name
  • Z-domain of protein A
  • Origin
  • Staphylococcal protein A
  • Core Structure
  • 3-α helixes
  • Variable Regions
  • 13 Residues on first and second helix surface
  • Target
  • Human apolipoprotein A-1 variant
  • Species Reactivity
  • Human
  • Expression Host
  • E. coli
  • Applications
  • ELISA; IHC; Microscopy; FC; WB; FuncS

Target

  • Alternative Names
  • Staphylococcal protein A; Z-domain of protein A; apo(a)

Downloads

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Single-domain Antibody

CAT Product Name Application Type
NABL-071 Recombinant Anti-human APOA1 VHH Single Domain Antibody WB, ELISA, IP, FuncS Llama VHH

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0048MZ Chicken Anti-APOA1 Polyclonal IgY Indirect ELISA, WB Chicken antibody
BRD-0784MZ Chicken Anti-Apolipoprotein A1 Polyclonal IgY ICC, IF, IHC, WB Chicken antibody

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0204 Hi-Affi™ Rabbit Anti-APOA1 Recombinant Antibody (clone DS204AB) IF, IHC-P, IP, WB, sELISA Rabbit IgG
MOR-4531 Hi-Affi™ Rabbit Anti-APOA1 Recombinant Antibody (clone TH39DS) WB, IF, ICC, ELISA Rabbit IgG

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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