Z-domain of protein A scaffold protein anti-Human complement, component 5 (C5) (CAT#: SZA-L229)
This human complement, component 5 (C5) specific binding protein (Z-domain of protein A) was investigated by an α-helix shuffling strategy. The primary scaffold protein was from a naive combinatorial library of the three-helix bundle Z domain derived from staphylococcal protein A. A hierarchical library was constructed through selective re-randomization of six amino acid positions in one of the two α-helices of the domain, making up the Taq DNA polymerase binding surface. After selections using monovalent phage display technology, second generation variants were identified having affinities for human complement, component 5 (C5) as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
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RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (A549, Hep G2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000106804-C5
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000106804-C5
Specifications
- Scaffold Name
- Z-domain of protein A
- Origin
- Staphylococcal protein A
- Core Structure
- 3-α helixes
- Variable Regions
- 13 Residues on first and second helix surface
- Target
- Human complement, component 5 (C5)
- Species Reactivity
- Human
- Expression Host
- E. coli
- Applications
- ELISA; IHC; Microscopy; FC; WB; FuncS
Target
- Alternative Names
- Staphylococcal protein A; Z-domain of protein A; C5D; C5a; C5b; ECLZB; CPAMD4
- Gene ID
- 727
- UniProt ID
- P01031
Related Resources
Systemic Lupus Erythematosus
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See other products for "C5"
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-901 | Anti-Human C5 Recombinant Antibody (Pexelizumab) | FuncS, IF, Neut, ELISA, FC, IP, ICC | scFv |
| TAB-008 | Anti-Human C5 Recombinant Antibody (Eculizumab) | ELISA, FC, IP, FuncS, IF, Neut, WB | IgG2 / G4 - kappa |
| TAB-1372CL-S(P) | Human Anti-C5 Recombinant Antibody; scFv Fragment (TAB-1372CL-S(P)) | Inhib, FuncS | Human scFv |
| TAB-1373CL-S(P) | Human Anti-C5 Recombinant Antibody; scFv Fragment (TAB-1373CL-S(P)) | IB, Inhib | Humanized scFv |
| TAB-1374CL-S(P) | Human Anti-C5 Recombinant Antibody; scFv Fragment (TAB-1374CL-S(P)) | ELISA, Inhib | Humanized scFv |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1370CL-S(P) | Mouse Anti-C5 Recombinant Antibody; scFv Fragment (TAB-1370CL-S(P)) | ELISA | Mouse scFv |
| TAB-1371CL-S(P) | Mouse Anti-C5 Recombinant Antibody; scFv Fragment (TAB-1371CL-S(P)) | Inhib, FuncS | Mouse scFv |
| TAB-1382CL-S(P) | Mouse Anti-C5 Recombinant Antibody; scFv Fragment (TAB-1382CL-S(P)) | ELISA, Inhib | Mouse scFv |
| TAB-1383CL-S(P) | Mouse Anti-C5 Recombinant Antibody; scFv Fragment (TAB-1383CL-S(P)) | ELISA, Inhib | Mouse scFv |
| TAB-1366CL-F(E) | Mouse Anti-C5 Recombinant Antibody; Fab Fragment (TAB-1366CL-F(E)) | ELISA, Inhib | Mouse Fab |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-083CQ | Mouse Anti-C5 Recombinant Antibody (clone MM0608-6H13) | ELISA, Neut, WB | Mouse IgG1 |
| NEUT-084CQ | Mouse Anti-C5 Recombinant Antibody (clone CBL030) | ELISA, WB, Neut | Mouse IgG1 |
| NEUT-085CQ | Mouse Anti-C5 Recombinant Antibody (clone CBL250) | ELISA, WB, IHC, FuncS | Mouse IgG1 |
| NEUT-086CQ | Mouse Anti-C5 Recombinant Antibody (clone G25/2) | ELISA, IP, WB, Neut | Mouse IgG1, κ |
| NEUT-087CQ | Mouse Anti-C5 Recombinant Antibody (clone 561) | ELISA, Neut | Mouse IgG2a |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-088CQ | Mouse Anti-C5 Recombinant Antibody (clone CBL771) | WB, Block, ELISA | Mouse IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4104 | Hi-Affi™ Rabbit Anti-C5 Recombinant Antibody (clone SI175DS) | IHC-P | Rabbit IgG |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-453CQ | Anti-Human C5 Recombinant Antibody (Tesidolumab) | ELISA, IHC, FC, IP, IF, FuncS | IgG1, λ2 |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0609-CN | Human Anti-C5 Recombinant Antibody (HPAB-0609-CN) | ELISA, Block | Humanized IgG |
| HPAB-0611-CN | Rabbit Anti-C5 Recombinant Antibody (HPAB-0611-CN) | PK, SPR, IF, ELISA, WB, FC | Rabbit IgG |
| HPAB-0612-CN | Human Anti-C5 Recombinant Antibody (HPAB-0612-CN) | PK, WB, ELISA, FC | Humanized IgG |
| HPAB-0613-CN | Human Anti-C5 Recombinant Antibody (HPAB-0613-CN) | WB, ELISA, FC | Humanized IgG |
| HPAB-0614-CN | Mouse Anti-C5 Recombinant Antibody (clone m5G1.1) | Inhib, FuncS, WB, ELISA, IF, IP, Block | Mouse IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0123-LS-F(E) | Mouse Anti-C5 Recombinant Antibody; Fab Fragment (HPAB-0123-LS-F(E)) | Block, ELISA | Mouse Fab |
| HPAB-0124-LS-F(E) | Mouse Anti-C5 Recombinant Antibody; Fab Fragment (HPAB-0124-LS-F(E)) | Block, ELISA | Mouse Fab |
| HPAB-0652LY-F(E) | Mouse Anti-C5 Recombinant Antibody; Fab Fragment (HPAB-0652LY-F(E)) | IP, RIA, ELISA, WB | Mouse Fab |
| HPAB-0653LY-F(E) | Mouse Anti-C5 Recombinant Antibody; Fab Fragment (HPAB-0653LY-F(E)) | IP, RIA, ELISA, WB | Mouse Fab |
| HPAB-0654LY-F(E) | Mouse Anti-C5 Recombinant Antibody; Fab Fragment (HPAB-0654LY-F(E)) | IP, RIA, ELISA, WB | Mouse Fab |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABC-559 | Recombinant Llama Anti-C5 Single Domain Antibody (Nb36) | ELISA | Llama VHH |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-453CQ | Afuco™ Anti-C5 ADCC Recombinant Antibody (Tesidolumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| AFC-TAB-008 | Afuco™ Anti-C5 ADCC Recombinant Antibody (Eculizumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
| AFC-TAB-436CQ | Afuco™ Anti-C5 ADCC Recombinant Antibody (Olendalizumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0080-WJ-S(P) | Human Anti-C5 Recombinant Antibody; scFv Fragment (HPAB-0080-WJ-S(P)) | ELISA, FC | Humanized scFv |
| HPAB-1484-FY-F(E) | Mouse Anti-C5 Recombinant Antibody; Fab Fragment (HPAB-1484-FY-F(E)) | ELISA, Neut | Mouse Fab |
| HPAB-1485-FY-F(E) | Mouse Anti-C5 Recombinant Antibody; Fab Fragment (HPAB-1485-FY-F(E)) | ELISA, Neut | Mouse Fab |
| HPAB-0527-YJ-S(P) | Human Anti-C5 Recombinant Antibody; scFv Fragment (HPAB-0527-YJ-S(P)) | ELISA, Inhib, FuncS | Humanized scFv |
| HPAB-1577WJ-S(P) | Mouse Anti-C5 Recombinant Antibody; scFv Fragment (clone 5G1.1) | ELISA, WB | Mouse scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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