Z-domain of protein A scaffold protein anti-Human PDE4D5 (CAT#: SZA-L235)

This PDE4D5 specific binding protein (Z-domain of protein A) was investigated by an α-helix shuffling strategy. The primary scaffold protein was from a naive combinatorial library of the three-helix bundle Z domain derived from staphylococcal protein A. A hierarchical library was constructed through selective re-randomization of six amino acid positions in one of the two α-helices of the domain, making up the Taq DNA polymerase binding surface. After selections using monovalent phage display technology, second generation variants were identified having affinities (KD=7pM) for PDE4D5 as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.


Specific Inquiry
  • Size:
  • Conjugation:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Scaffold Name
  • Z-domain of protein A
  • Origin
  • Staphylococcal protein A
  • Core Structure
  • 3-α helixes
  • Variable Regions
  • 13 Residues on first and second helix surface
  • Target
  • PDE4D5
  • Species Reactivity
  • Human
  • Expression Host
  • E. coli
  • Affinity Constant
  • 7pM
  • Applications
  • ELISA; IHC; Microscopy; FC; WB; FuncS

Target

  • Alternative Names
  • Staphylococcal protein A; Z-domain of protein A; DPDE3; PDE43; STRK1; ACRDYS2; HSPDE4D; PDE4DN2

Related Resources

  • Related Signaling Pathways

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "PDE4D"

Rabbit Monoclonal Antibody

Recombinant Antibody

CAT Product Name Application Type
ZG-0030U Rabbit Anti-PDE4D Recombinant Antibody (clone 4D4) ELISA, WB Rabbit IgG

Customer Reviews and Q&As

Submit a review or a question
There are currently no Customer reviews or questions for SZA-L235. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.

For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

© 2024 Creative Biolabs.
  • 0
  • 0
Cart

    Go to compare