This PDGFRβ specific binding protein (Z-domain of protein A) was investigated by an α-helix shuffling strategy. The primary scaffold protein was from a naive combinatorial library of the three-helix bundle Z domain derived from staphylococcal protein A. A hierarchical library was constructed through selective re-randomization of six amino acid positions in one of the two α-helices of the domain, making up the Taq DNA polymerase binding surface. After selections using monovalent phage display technology, second generation variants were identified having affinities (KD=84 pM) for PDGFRβ as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-706CL | Anti-Human PDGFRB Therapeutical Antibody (IMC-2C5) | Inhib, FuncS | Antibody |
TAB-0988CL-S(P) | Human Anti-PDGFRB Recombinant Antibody; scFv Fragment (TAB-0988CL-S(P)) | ELISA | Human scFv |
TAB-0989CL-S(P) | Human Anti-PDGFRB Recombinant Antibody; scFv Fragment (TAB-0989CL-S(P)) | ELISA | Human scFv |
TAB-0990CL-S(P) | Human Anti-PDGFRB Recombinant Antibody; scFv Fragment (TAB-0990CL-S(P)) | ELISA | Human scFv |
TAB-0991CL-S(P) | Human Anti-PDGFRB Recombinant Antibody (TAB-0991CL-S(P)); scFv Fragment | ELISA | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1850CQ | Recombinant Rat Anti-Pdgfrb Antibody (APB5) | FC, FuncS, Neut | IgG2a, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-2638 | Hi-Affi™ Recombinant Rabbit Anti-PDGFRB Monoclonal Antibody (DS2638AB) | WB | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0281CQ | Human Anti-PDGFRB Recombinant Antibody (clone 1B3) | ELISA, FC, WB, Neut | Human IgG |
MRO-1193-CN | Recombinant Rabbit Anti-PDGFRB Monoclonal Antibody (CBACN-438) | WB, IHC, IP | Rabbit IgG |
HPAB-1110-CN | Mouse Anti-PDGFRB Recombinant Antibody (HPAB-1110-CN) | ELISA | Mouse IgG1 |
HPAB-1111-CN | Human Anti-PDGFRB Recombinant Antibody (HPAB-1111-CN) | ELISA | Human IgG4 |
HPAB-1112-CN | Human Anti-PDGFRB Recombinant Antibody (HPAB-1112-CN) | ELISA | Human IgG4 |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0281CQ-F(E) | Human Anti-PDGFRB Recombinant Antibody (clone 1B3); Fab Fragment | ELISA, FC, WB, Neut | Human Fab |
HPAB-1110-CN-F(E) | Mouse Anti-PDGFRB Recombinant Antibody; Fab Fragment (HPAB-1110-CN-F(E)) | ELISA | Mouse Fab |
HPAB-1111-CN-F(E) | Human Anti-PDGFRB Recombinant Antibody; Fab Fragment (HPAB-1111-CN-F(E)) | ELISA | Human Fab |
HPAB-1112-CN-F(E) | Human Anti-PDGFRB Recombinant Antibody; Fab Fragment (HPAB-1112-CN-F(E)) | ELISA | Human Fab |
HPAB-1113-CN-F(E) | Human Anti-PDGFRB Recombinant Antibody; Fab Fragment (HPAB-1113-CN-F(E)) | ELISA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0281CQ-S(P) | Human Anti-PDGFRB Recombinant Antibody (clone 1B3); scFv Fragment | ELISA, FC, WB, Neut | Human scFv |
HPAB-S0105-YC-S(P) | Mouse Anti-PDGFRB Recombinant Antibody (clone muM4TS.11); scFv Fragment | ELISA, Neut | Mouse scFv |
HPAB-S0106-YC-S(P) | Human Anti-PDGFRB Recombinant Antibody (clone HuM4TS.11); scFv Fragment | ELISA, Neut | Humanized scFv |
HPAB-S0107-YC-S(P) | Mouse Anti-PDGFRB Recombinant Antibody (clone muM4TS.22); scFv Fragment | ELISA, Neut | Mouse scFv |
HPAB-S0108-YC-S(P) | Human Anti-PDGFRB Recombinant Antibody (clone HuM4TS.22); scFv Fragment | ELISA, Neut | Humanized scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-448CQ | Afuco™ Anti-PDGFRB Recombinant Antibody (AFC-TAB-448CQ), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | Human IgG1, κ |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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