This hRaf-1 specific binding protein (Z-domain of protein A) was investigated by an α-helix shuffling strategy. The primary scaffold protein was from a naive combinatorial library of the three-helix bundle Z domain derived from staphylococcal protein A. A hierarchical library was constructed through selective re-randomization of six amino acid positions in one of the two α-helices of the domain, making up the Taq DNA polymerase binding surface. After selections using monovalent phage display technology, second generation variants were identified having affinities (KD=1.9 μm) for hRaf-1 as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1388CT | Recombinant Mouse anti-Human RAF1 Monoclonal antibody (520) | WB | |
MRO-1316-CN | Recombinant Rabbit Anti-RAF1 Monoclonal Antibody (CBACN-476) | WB, IF | Rabbit IgG |
MRO-2367-CN | Recombinant Rabbit Anti-RAF1 (phosphorylated Ser259) Monoclonal Antibody (CBACN-653) | WB, IHC | Rabbit IgG |
MRO-2368-CN | Recombinant Rabbit Anti-RAF1 (phosphorylated Ser43) Monoclonal Antibody (CBACN-654) | WB | Rabbit IgG |
MRO-2369-CN | Recombinant Rabbit Anti-RAF1 (phosphorylated Ser621) Monoclonal Antibody (CBACN-655) | WB | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
BRD-0796MZ | Chicken Anti-c-Raf Polyclonal IgY | ICC, IF, IHC, WB | Chicken antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-2982 | Hi-Affi™ Recombinant Rabbit Anti-RAF1 Monoclonal Antibody (DS2982AB) | IP, IHC-P, ICC/IF, WB | IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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