Anti-RON (clone Zt/g4)-SMCC-DM1 ADC (CAT#: ADC-228LZY)

This ADC product is composed of an anti-RON antibody (clone Zt/g4) conjugated via SMCC linker to DM1 (Zt/g4-SMCC-DM1). It has demonstrated a response in Colorectal Cancer treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Antibody Overview
  • Mouse Anti-RON IgG1a/κ,Zt/g4
  • Clone
  • Zt/g4
  • Linker
  • SMCC (4-[N-maleimidomethyl] cyclohexane-1 carboxylhydrazide).
  • Linker Class/Description
  • Class: Noncleavable linker
    Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation
  • Drug
  • DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
  • Drug Class/Description
  • Class: Maytansinoid
    Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
    macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells

Target

  • Introduction
  • This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternatively spliced transcript variants encoding different isoforms with different structural and biochemical properties have been described (PMID:8816464). [provided by RefSeq, Oct 2011]
  • Alternative Names
  • MST1R; macrophage stimulating 1 receptor (c-met-related tyrosine kinase); RON; PTK8; CD136; CDw136; macrophage-stimulating protein receptor; p185-Ron; MSP receptor; RON variant 21; RON variant E2E3; MST1R variant RON30; MST1R variant RON62; soluble RON variant 1; soluble RON variant 2; soluble RON variant 3; soluble RON variant 4; c-met-related tyrosine kinase; PTK8 protein tyrosine kinase 8;

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Recombinant Antibody

CAT Product Name Application Type
MOB-3123z Mouse Anti-MST1R Recombinant Antibody (clone 29B12) WB, IP, IF, ELISA Mouse IgG1, κ
MOB-1279MZ Recombinant Mouse Anti-Human MST1R Antibody (clone 2C6B0) ELISA, WB Mouse antibody
HPAB-0265CQ Human Anti-MST1R Recombinant Antibody (clone IMC-41A2) ELISA, WB, FC, IP Human IgG1, κ
HPAB-0266CQ Human Anti-MST1R Recombinant Antibody (clone IMC-41A10) ELISA, WB, FC, IP, Block Human IgG1, κ
HPAB-0267CQ Human Anti-MST1R Recombinant Antibody (clone IMC-41B12) ELISA, WB, FC, IP, Block Human IgG1, κ

Blocking Antibody

CAT Product Name Application Type
NEUT-1756CQ Recombinant Mouse Anti-MST1R Antibody (CBL312) BL IgG1

Neutralizing Antibody

CAT Product Name Application Type
NEUT-1757CQ Recombinant Mouse Anti-MST1R Antibody (MM0478-10F24) Neut IgG1

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-2309 Hi-Affi™ Recombinant Rabbit Anti-MST1R Monoclonal Antibody (DS2309AB) FC, ICC/IF, IHC-P, IP, WB IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-184 Afuco™ Anti-MST1R ADCC Recombinant Antibody (Narnatumab), ADCC Enhanced FuncS, IF, Neut, ELISA, FC, IP ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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