Anti-CD324-PBD dimers ADC (CAT#: ADC-358CL)

This ADC product is composed of an anti-CD324 antibody conjugated via linker to PBD dimers(anti-CD324-PBD). It has demonstrated a response in treatment by a MOA (Mechanism of Action) of binding to DNA minor groove and causing DNA damage.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Antibody Overview
  • Anti-CD324 Antibody
  • Drug
  • pyrrolobenzodiazepine (PBD) dimers
  • Drug Class/Description
  • Class: Pyrrolobenzodiazepine (PBD) dimmers
    Description: Pyrrolobenzodiazepine (PBD) dimmers are highly cytotoxic DNA cross-linking agents. PBDs exert their biological activity through covalent binding via their N10-C11imine/carbinolamine moieties to the C2-amino position of a guanine residue within the minor groove of DNA.

Target

  • Introduction
  • This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq, Jul 2008]
  • Alternative Names
  • CDH1; cadherin 1, type 1, E-cadherin (epithelial); UVO; CDHE; ECAD; LCAM; Arc-1; CD324; cadherin-1; CAM 120/80; E-Cadherin; uvomorulin; cell-CAM 120/80; epithelial cadherin; cadherin 1, E-cadherin (epithelial); calcium-dependent adhesion protein, epithelial;

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Humanized Antibody

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0111MZ Chicken Anti-CDH1 Polyclonal IgY WB Chicken antibody

Neutralizing Antibody

CAT Product Name Application Type
NEUT-440CQ Rat Anti-CDH1 Recombinant Antibody (clone DECMA-1) FC, FuncS, Neut, WB, IF, IP Rat IgG1, κ

Blocking Antibody

CAT Product Name Application Type
NEUT-441CQ Rat Anti-Cdh1 Recombinant Antibody (clone ECCD-1) IHC-Fr, Block, ICC, IF, WB Rat IgG1
NEUT-442CQ Mouse Anti-CDH1 Recombinant Antibody (VMC173) ELISA, FC, ICC, IF, IHC, IP, WB, IHC-P, IHC-Fr, Block Mouse IgG1
NEUT-443CQ Mouse Anti-CDH1 Recombinant Antibody (VMC174) ELISA, IP, WB, ICC, Block, FC, IHC-P Mouse IgG2a

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0611 Hi-Affi™ Rabbit Anti-CDH1 Recombinant Antibody (clone DS611AB) ICC, IF, IHC-P, IHC-P, IP, WB Rabbit IgG
MOR-4569 Hi-Affi™ Rabbit Anti-CDH1 Recombinant Antibody (clone TH81DS) WB, IF, ICC, FC Rabbit IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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