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Anti-CDH3-sulfo-SMCC-ADC (CAT#: ADC-242CL)

This ADC product is composed of an anti-CDH3 antibody conjugated via sulfo-SMCC linker to drug payload (anti-CDH3-sulfo-SMCC).


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Figure 1 IF staining of human cell line CACO-2
Figure 1 IF staining of human cell line CACO-2
(Immunofluorescent staining of human cell line CACO-2 shows localization to plasma membrane & cell junctions.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1767/1032_G9_1_selected.jpg
Normal Tissue
Figure 2 Skin 1
Figure 2 Skin 1
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1767/8164_B_8_1_val_selected.jpg
Figure 3 Oral mucosa
Figure 3 Oral mucosa
(Squamous epithelial cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1767/8164_A_8_1.jpg
Figure 4 Colon
Figure 4 Colon
(Glandular cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1767/8164_A_8_3.jpg
Figure 5 Liver
Figure 5 Liver
(Cholangiocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1767/8164_A_7_4.jpg
Figure 6 Kidney
Figure 6 Kidney
(Collecting ducts Staining: Medium Intensity: Moderate Quantity:>75% Distal tubules Staining: Medium Intensity: Moderate Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1767/8164_A_8_5.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (A-431, HaCaT, HBEC3-KT, hTCEpi, hTERT-HME1, RPTEC TERT1)
Figure 7 RNA cell line category: Cell line enhanced (A-431, HaCaT, HBEC3-KT, hTCEpi, hTERT-HME1, RPTEC TERT1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000062038-CDH3

Specifications

  • Antibody Overview
  • Anti-Human CDH3 Chimeric Antibody
  • Linker
  • sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late)
  • Linker Class/Description
  • Class: Noncleavable linkers
    Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.

Target

  • Introduction
  • This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy. [provided by RefSeq, Jul 2008]
  • Alternative Names
  • CDH3; cadherin 3, type 1, P-cadherin (placental); CDHP; HJMD; PCAD; cadherin-3; calcium-dependent adhesion protein, placental;

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See other products for "CDH3"

Mouse Antibody

CAT Product Name Application Type
TAB-0943CL Mouse Anti-CDH3 Recombinant Antibody (TAB-0943CL) Inhib Mouse IgG
TAB-0943CL-S(P) Mouse Anti-CDH3 Recombinant Antibody; scFv Fragment (TAB-0943CL-S(P)) SDS-PAGE Mouse scFv
TAB-0943CL-F(E) Mouse Anti-CDH3 Recombinant Antibody; Fab Fragment (TAB-0943CL-F(E)) SDS-PAGE Mouse Fab

Human Antibody

CAT Product Name Application Type
TAB-0944CL Human Anti-CDH3 Recombinant Antibody (TAB-0944CL) ELISA Human IgG
TAB-0944CL-S(P) Human Anti-CDH3 Recombinant Antibody; scFv Fragment (TAB-0944CL-S(P)) ELISA Human scFv
TAB-0944CL-F(E) Human Anti-CDH3 Recombinant Antibody; Fab Fragment (TAB-0944CL-F(E)) ELISA Human Fab

Blocking Antibody

CAT Product Name Application Type
NEUT-446CQ Mouse Anti-CDH3 Recombinant Antibody (VMC175) ICC, IF, WB, IP, Block Mouse IgG1
NEUT-447CQ Mouse Anti-CDH3 Recombinant Antibody (clone NCC-CAD-299) IHC-Fr, Inhib, WB Mouse IgG1
NEUT-448CQ Rat Anti-Cdh3 Recombinant Antibody (clone PCD-1) ELISA, Inhib, IF, WB, IHC-P, IHC-Fr, FC, IV Rat IgG2a

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0619 Hi-Affi™ Rabbit Anti-CDH3 Recombinant Antibody (clone DS619AB) WB, IP, FC, IHC-P, ICC, IF Rabbit IgG

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0142CQ-S(P) Human Anti-CDH3 Recombinant Antibody (clone 194-b09); scFv Fragment ELISA, FC Human scFv
HPAB-0143CQ-S(P) Human Anti-CDH3 Recombinant Antibody (clone 194-g09); scFv Fragment ELISA, FC Human scFv
HPAB-0144CQ-S(P) Human Anti-CDH3 Recombinant Antibody (clone 196-g03); scFv Fragment ELISA, FC Human scFv
HPAB-0400-YJ-S(P) Human Anti-CDH3 Recombinant Antibody; scFv Fragment (HPAB-0400-YJ-S(P)) ELISA, FuncS Human scFv
HPAB-0401-YJ-S(P) Human Anti-CDH3 Recombinant Antibody; scFv Fragment (HPAB-0401-YJ-S(P)) ELISA, FuncS Human scFv

Recombinant Antibody

CAT Product Name Application Type
PABC-251 Mouse Anti-CDH3 Recombinant Antibody (clone TSP7) ELISA, Inhib, Live cell imaging Mouse IgG
PABC-252 Mouse Anti-CDH3 Recombinant Antibody (clone TSP11) ELISA, Inhib, Live cell imaging Mouse IgG
PABC-253 Mouse Anti-CDH3 Recombinant Antibody (clone TSP5) ELISA, Inhib, Live cell imaging Mouse IgG
HPAB-2071LY Human Anti-CDH3 Recombinant Antibody (HPAB-2071LY) ELISA Human IgG
HPAB-0390-FY Human Anti-CDH3 Recombinant Antibody (HPAB-0390-FY) IHC Human IgG1

Fab Fragment Antibody

CAT Product Name Application Type
PFBC-251 Mouse Anti-CDH3 Recombinant Antibody (clone TSP7); Fab Fragment ELISA, Inhib, Live cell imaging Mouse Fab
PFBC-252 Mouse Anti-CDH3 Recombinant Antibody (clone TSP11); Fab Fragment ELISA, Inhib, Live cell imaging Mouse Fab
PFBC-253 Mouse Anti-CDH3 Recombinant Antibody (clone TSP5); Fab Fragment ELISA, Inhib, Live cell imaging Mouse Fab
HPAB-0400-YJ-F(E) Human Anti-CDH3 Recombinant Antibody; Fab Fragment (HPAB-0400-YJ-F(E)) ELISA, FuncS Human Fab
HPAB-0401-YJ-F(E) Human Anti-CDH3 Recombinant Antibody; Fab Fragment (HPAB-0401-YJ-F(E)) ELISA, FuncS Human Fab

MHC Tetramer for Cancer

CAT Product Name Application Type
MHC-CN0513 PE-A*24:02/Human CDH3 (DYLNEWGSRF) MHC Tetramer FCM, IHC
MHC-CN0514 APC-A*24:02/Human CDH3 (DYLNEWGSRF) MHC Tetramer FCM, IHC
MHC-CN0515 FITC-A*24:02/Human CDH3 (DYLNEWGSRF) MHC Tetramer FCM, IHC
MHC-CN0516 A*24:02/Human CDH3 (DYLNEWGSRF) MHC Tetramer FCM, IHC
MHC-YF359 A*24:02/Human CDH3 (DYLNEWGSRF) MHC Pentamer FCM

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